ID   HRCA_SYMTH              Reviewed;         341 AA.
AC   Q67S56;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=STH502;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP006840; BAD39487.1; -; Genomic_DNA.
DR   RefSeq; WP_011194636.1; NC_006177.1.
DR   AlphaFoldDB; Q67S56; -.
DR   SMR; Q67S56; -.
DR   STRING; 292459.STH502; -.
DR   EnsemblBacteria; BAD39487; BAD39487; STH502.
DR   KEGG; sth:STH502; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_9; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..341
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182546"
SQ   SEQUENCE   341 AA;  38714 MW;  FB498EB9D2C3DCB0 CRC64;
     MIDDRKNKVL QAIIEDYVAT AEPVGSRTIA RKYNLGVSPA TIRNEMSDLE ELGYLEQPHT
     SAGRIPSNLG YRYYVDCLMP ERPINPAEQE LIRSTFQRKI RELDTLVRET ARLLSETTHL
     TAVISGPQFE KAVFKEIRIV PLGNDRALLI YITDSGLVEN QVVEVPLQVT MLELQQVAEL
     LSEHLRGRRV ETLSRTALQS LHRELSRYGT LLEQALHFLE QKLEPGDRHR LYFGGTSHML
     DQPEFRDVQK LRGVLSFLEQ EEAVAAVLGL DRLTEGVEIQ IGEEIRLREL ADCSVVTATY
     RVGDRIIGKM GVIGPRRMEY PKVVSILNAI ASHLSEMNRL F