ID   HRCA_SYNJA              Reviewed;         392 AA.
AC   Q2JRN9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CYA_2590;
OS   Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS   A-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-3-3Ab;
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000239; ABD00707.1; -; Genomic_DNA.
DR   RefSeq; WP_011431380.1; NC_007775.1.
DR   AlphaFoldDB; Q2JRN9; -.
DR   SMR; Q2JRN9; -.
DR   STRING; 321327.CYA_2590; -.
DR   EnsemblBacteria; ABD00707; ABD00707; CYA_2590.
DR   KEGG; cya:CYA_2590; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008818; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..392
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010468"
SQ   SEQUENCE   392 AA;  43291 MW;  A287B080BDF7E5B0 CRC64;
     MKLELTPRQR KILWATVRRY IATAEPVGSK TLAQSYNLGV STATIRNDLA TLEQVGLLFQ
     PHTSAGRIPS DFGYRVYVND LLSSANMDGI PNDAPQPEPH PALQQLLDQL NRELGDDLDS
     FLQRVAQLLA HLSGCIALIT PPQGPVVAVH HVQLLSVGPG RVMVLVVTDS YQTHSALVSP
     PDWPDDRRED LEDELQLLSN FLTLKLRGKT FAELQDLSWL KLDEEFRAYS HWLQQLLRSV
     VQRYLRPSLG QVFSAGMTEL MRQPEFSQAQ RMQAVAQLLE EGSEQLQGMI GLYSTPGCLF
     TSEAALSAPS AREKASSSTA DQDPSHNVPV IIYIGSENPL ESLHHCTVIA SVYRRRSAPL
     GTVTLLGPTR MAYERSIAAV QTVASHLTRA LA