ID   HRCA_SYNJB              Reviewed;         389 AA.
AC   Q2JJ73;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CYB_2369;
OS   Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium
OS   Yellowstone B-Prime).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=321332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA-2-3B'a(2-13);
RX   PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA   Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA   Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT   "Population level functional diversity in a microbial community revealed by
RT   comparative genomic and metagenomic analyses.";
RL   ISME J. 1:703-713(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000240; ABD03308.1; -; Genomic_DNA.
DR   RefSeq; WP_011433937.1; NC_007776.1.
DR   AlphaFoldDB; Q2JJ73; -.
DR   SMR; Q2JJ73; -.
DR   STRING; 321332.CYB_2369; -.
DR   KEGG; cyb:CYB_2369; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001938; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..389
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010469"
SQ   SEQUENCE   389 AA;  42701 MW;  73506390C5667788 CRC64;
     MKLELTPRQR KILWATVRSY IATAEPVGSK TLAQSYNFGV STATIRNDLA TLEQVGLLFQ
     PHTSAGRVPS DFGYRVYVND LLTSANSGGI PHDAPQPDPH PALQQLMDQL GRELGDDLDS
     LLQRVAQLLA HLSGCIALIT PPQGPVVAIH HVQLVSVAPG RVMVLVVTDS YQTHSALVSP
     PDWPSDSRED LEDELQLLSN FLTLKLRGKT FAELQDLSWL KLDEEFRTYG HWLQQLLRSV
     VQRCLQPSLG QVFSAGMAEL MRQPEFSQAR QVQAVMQLIE EGAKQLQGMI GLHFADGGDP
     QLAYLPPLPS STEMDQESGQ SARKTPVIIY IGSENPLESL HHCTVIASTY HRRSAPLGTV
     TLLGPTRMAY ERSIAAVQAV ASHLTRALA