ID   HRCA_SYNP6              Reviewed;         353 AA.
AC   Q5N3M2;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=syc0908_c;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AP008231; BAD79098.1; -; Genomic_DNA.
DR   RefSeq; WP_011243220.1; NC_006576.1.
DR   AlphaFoldDB; Q5N3M2; -.
DR   SMR; Q5N3M2; -.
DR   STRING; 269084.syc0908_c; -.
DR   EnsemblBacteria; BAD79098; BAD79098; syc0908_c.
DR   KEGG; syc:syc0908_c; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..353
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182548"
SQ   SEQUENCE   353 AA;  38806 MW;  54379761C9C48F98 CRC64;
     MLVSRLTARQ QTILSATVRH YVRTAEPVGS KALAEQYGLS VSAATIRNAM GVLERAGLLY
     QPHTSAGRVP SEGGYRLYVD QLMEPDRALQ RQTEQQLSQQ LPDRRQSLEA LLRGAAQILA
     SLSGYLSLIT FPLGLEFQVR HLQLVAIAPH QVLLIVVNDS YETQSALLTL PELDRDLEAD
     QLDRQLLLLS NFLNQELQGR SLQALANLDW PVLGSELQSL AGILQQGLQD LEKRWQPTPA
     TSLLVCGLAD LLRQPEFNEL QQVQALLELL EGEQTQLLPL MLADPAADQV RVRIGSELPL
     APIRSCSLVS AFYCREQQPV GSVSLIGPTR MLYENAVAAV EATASYLSEA IAS