ID   HRCA_SYNPW              Reviewed;         331 AA.
AC   A5GP57;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=SynWH7803_2296;
OS   Synechococcus sp. (strain WH7803).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=32051;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WH7803;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CT971583; CAK24722.1; -; Genomic_DNA.
DR   RefSeq; WP_011934183.1; NC_009481.1.
DR   AlphaFoldDB; A5GP57; -.
DR   SMR; A5GP57; -.
DR   STRING; 32051.SynWH7803_2296; -.
DR   EnsemblBacteria; CAK24722; CAK24722; SynWH7803_2296.
DR   KEGG; syx:SynWH7803_2296; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001566; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..331
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010471"
SQ   SEQUENCE   331 AA;  36449 MW;  0E8507DF7695AD11 CRC64;
     MELLPRRQQE VLQATVHHYV DTIEPVGSKT LVQRFGLQAS SATVRSAMGA LEQKGLLVQP
     HPSAGRIPSP RGYRHYVDCL LPKPGAAVHH LEQELTQLSL RWAALDDLLQ QLTRRLTDFT
     GLMSLITLPQ PSEQRLHAIR LVPTDERLLV MLVADSSQTH HLNLRLPHGS VHQVAALERW
     TDDQLHQSGQ ISWESLPQQL QTCGQALREA LHNEEGRFIS PSDQSAHVHG VSRLVAQPEF
     SDSTKVAPLL DLMDCNPAAF IPSGPGHDDW VWIGGEHPHT ALSDCSVIQS SYRDGQGGVG
     QVALVGPMRM AYATARAAVQ CVAKHLNHLL S