ID   HRCA_SYNR3              Reviewed;         330 AA.
AC   A5GWB6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=SynRCC307_2272;
OS   Synechococcus sp. (strain RCC307).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=316278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC307;
RG   Genoscope;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CT978603; CAK29175.1; -; Genomic_DNA.
DR   RefSeq; WP_011936684.1; NC_009482.1.
DR   AlphaFoldDB; A5GWB6; -.
DR   SMR; A5GWB6; -.
DR   STRING; 316278.SynRCC307_2272; -.
DR   EnsemblBacteria; CAK29175; CAK29175; SynRCC307_2272.
DR   KEGG; syr:SynRCC307_2272; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000001115; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..330
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010472"
SQ   SEQUENCE   330 AA;  35271 MW;  DE558ABE721D4B6C CRC64;
     MLPLPRRQQQ VLQATVQHYV DTVEPVGSRT LVRRFGLDAS PATVRSAMGA LEQKGLLTQP
     HTSAGRVPSP KGYRQFVDAL LPEPGAAVVQ LQRELAELSL QWAALDDLLH HLARRLADLT
     GLMSIITRPQ RQEPRLKALR LVRSGDRLLV FLVESSAASS SLNLRLPPDS SAQLQALEHW
     LNDQLSKSAI NWSGLPSHLQ SVGAPLKQAL ASHNRGRNRQ AEGALTTGLA GLLCQPEFQL
     TTSLRPLLQL VEQQPHELLN PAAATASGGV WIGQEHPHPA LSGCAVVQAP YATASGGEGS
     VALVGPMRMA YATALAAVEA VAGTLSRLLA