ID   HRCA_SYNY3              Reviewed;         378 AA.
AC   P72795;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=sll1670;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000022; BAA16810.1; -; Genomic_DNA.
DR   PIR; JC5689; JC5689.
DR   AlphaFoldDB; P72795; -.
DR   SMR; P72795; -.
DR   STRING; 1148.1651883; -.
DR   PaxDb; P72795; -.
DR   EnsemblBacteria; BAA16810; BAA16810; BAA16810.
DR   KEGG; syn:sll1670; -.
DR   eggNOG; COG1420; Bacteria.
DR   InParanoid; P72795; -.
DR   OMA; DYPGTMG; -.
DR   PhylomeDB; P72795; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..378
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182549"
SQ   SEQUENCE   378 AA;  42626 MW;  DBB24C059E04AFBC CRC64;
     MVKPLRLNDR HQQILRATVQ HYIATAEPVG SHTLAQEYQF AVSSATIRNA LGQLEKAGLL
     YQPHVSAGRV PSDSGYRIYV DNLLTWSDRQ SRTVKQRLEN EINGDNWHFE ALIQRMGQIL
     AGLSGYIALI TFPQTETVQL RHLQLMLLPS HQILIILVTD SYHTHSATLD LPAAMEAKEE
     GELEQELAIF SNFLNAQLRG KNLSELSHLN WQELDQKFSI YADFLKGLQQ QIKPLLQRRM
     AGPLVVHGVS KVIQQPEFSQ LEQVQMLLSL LEQEQDKLFS LLFDPDNYGD NLANLGQEMN
     LLTGETMPKT RPVVTIRIGA ENPLESMHPC TLVSAIYRQQ EIPMGSVSIL GPTRMVYQQT
     IPLVEQAAEC LSEALSKN