ID   HRCA_TETHA              Reviewed;         345 AA.
AC   Q93R29;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
OS   Tetragenococcus halophilus (Pediococcus halophilus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Tetragenococcus.
OX   NCBI_TaxID=51669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Fukuda D., Watanabe M., Sonezaki S., Sugimoto S., Sonomoto K., Ishizaki A.;
RT   "Characterization and expression analysis of dnaK operon of halophilic
RT   lactic acid bacterium Tetragenococcus halophila.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AB070346; BAB63288.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q93R29; -.
DR   SMR; Q93R29; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182551"
SQ   SEQUENCE   345 AA;  39039 MW;  FE6A6640A014CCE3 CRC64;
     MLTQRQDNIL HQIIHNYTNL GKPIGSKTLM EEGIAASSAT IRNEMKTLEE YGLLVKPHSS
     SGRIPSLKGY RYYVDYLLEP EKLKKSEVDV MQQSLGKDFH EINDIIEQSA KILSKLTSYT
     ALSIGPDVSN RKLTGFKMVP LNNRQVIAII VTDKGNVENQ VFSIPKSVDS EDLEKMVRII
     NDKLIGEPLL IVYQRLGTEI PMILHKYFQT TEGILDLFNN MLSEAFEEKI FVGGQMNLLN
     SDQIQNIDQF KSMLFMENSK QLNELLSTKD QPIQIRIGSE LGNDLLSDMS LIQANYEIKD
     HGNGTIALLG SASMPYSKML SLLDVFRQEL AETLDDYYRS IDSFG