HRCA_THEMA
ID HRCA_THEMA Reviewed; 338 AA.
AC Q9WZV5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=TM_0851;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000512; AAD35933.1; -; Genomic_DNA.
DR PIR; D72327; D72327.
DR RefSeq; NP_228660.1; NC_000853.1.
DR RefSeq; WP_004080775.1; NZ_CP011107.1.
DR PDB; 1STZ; X-ray; 2.20 A; A/B/C=1-338.
DR PDBsum; 1STZ; -.
DR AlphaFoldDB; Q9WZV5; -.
DR SMR; Q9WZV5; -.
DR STRING; 243274.THEMA_00385; -.
DR PRIDE; Q9WZV5; -.
DR EnsemblBacteria; AAD35933; AAD35933; TM_0851.
DR KEGG; tma:TM0851; -.
DR eggNOG; COG1420; Bacteria.
DR InParanoid; Q9WZV5; -.
DR OMA; LNWEEIE; -.
DR OrthoDB; 1510750at2; -.
DR EvolutionaryTrace; Q9WZV5; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Repressor; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..338
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182552"
FT HELIX 17..33
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 39..45
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 52..64
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 81..94
FT /evidence="ECO:0007829|PDB:1STZ"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 103..106
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 116..131
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 134..138
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 142..144
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 149..154
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 156..166
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 169..177
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 184..195
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 200..205
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 209..212
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 215..224
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 230..234
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 236..241
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 247..256
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 260..266
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 269..275
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 276..279
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 282..284
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 287..296
FT /evidence="ECO:0007829|PDB:1STZ"
FT STRAND 299..312
FT /evidence="ECO:0007829|PDB:1STZ"
FT HELIX 314..334
FT /evidence="ECO:0007829|PDB:1STZ"
SQ SEQUENCE 338 AA; 39307 MW; 02A505A546C313AE CRC64;
MRRLNRKNNE ALKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF SSATIRNDMK
KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE ADLAVETFKS MPLADPEKVL
FLAGNLLARL TEGYVLIERP NTRDLKILRV MLIPVSEDYL IFSILTEFGV SKVTPIKTQE
RLNWEEIERQ LNFLLRGRTV GEVLMGKIES LKGSGFLRLI ESLIGETVER YLDAGLENLL
KDETLTLEDI RNLLEEVKDQ KFLESLVGEG ITVRIGREIG RKKLEKFAVF SGKYFKGESP
IGSVYLFTSK VTKYDRNHRV FEYILNRLSE YFTSTSRR
