ID   HRCA_THENN              Reviewed;         339 AA.
AC   B9KAB7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=CTN_1724;
OS   Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=309803;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E;
RA   Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J.,
RA   Kim J.J., Park K.J., Lee S.Y.;
RT   "The genome sequence of the hyperthermophilic bacterium Thermotoga
RT   neapolitana.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000916; ACM23900.1; -; Genomic_DNA.
DR   RefSeq; WP_015920138.1; NC_011978.1.
DR   AlphaFoldDB; B9KAB7; -.
DR   SMR; B9KAB7; -.
DR   STRING; 309803.CTN_1724; -.
DR   EnsemblBacteria; ACM23900; ACM23900; CTN_1724.
DR   KEGG; tna:CTN_1724; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; LNWEEIE; -.
DR   Proteomes; UP000000445; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000118323"
SQ   SEQUENCE   339 AA;  39504 MW;  8B2632DC08C3B290 CRC64;
     MRRLSNKGEH QRNLNDRQRK VLYCIVKEYI ENKKPVSSQR VLEVSNINFS SATIRNDMKK
     LEYLGYIYQP HTSAGRVPTD KGLRFYYEEM VKLSKETEEL NLEVDTFRSI PLADPEKVLL
     LAGNLLARLA EGYVLIERPN PRDLKILRVM LIPVSEDYLI FSILTEFGIS KITPIRIHED
     LNWEEIERQL NFLLRGRTVE DVLTGKVETL RGSGILKLIE SVMNEKLERY IDVGFENLLK
     DDTLSLEDIK HLLEEIKDHR FLESLIGNDK DVTVKIGKEI GSKKLERFAV FSGRYYKGSS
     PIGSVHLFTS KITRYDRNHR VFNYVLNRLS EYFTSAARR