ID   HRCA_THEP1              Reviewed;         338 AA.
AC   A5IIT2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Tpet_0076;
OS   Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 /
OS   RKU-1).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=390874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermotoga petrophila RKU-1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000702; ABQ46105.1; -; Genomic_DNA.
DR   RefSeq; WP_011942779.1; NC_009486.1.
DR   AlphaFoldDB; A5IIT2; -.
DR   SMR; A5IIT2; -.
DR   STRING; 390874.Tpet_0076; -.
DR   EnsemblBacteria; ABQ46105; ABQ46105; Tpet_0076.
DR   KEGG; tpt:Tpet_0076; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   OMA; LNWEEIE; -.
DR   Proteomes; UP000006558; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..338
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010476"
SQ   SEQUENCE   338 AA;  39284 MW;  74EA05F2A0F344F1 CRC64;
     MRRLNRKNSD ASKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF SSATIRNDMK
     KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE ADLAVETFKS MPLADPEKVL
     FLAGNLLARL TEGYVLIERP NTRDLKILRV MLIPVSEDYL IFSILTEFGV SRVTPIKTQE
     RLNWEEIERQ LNFLLRGKTI GEVLLGRIES LKGSGFLRLI ESLIGETIER YLDAGLENLL
     KDETLALEDI RNLLEEIKDQ KFLESLVGEG ISVMIGREIG RKNLEKFAVF SGRYFKGESP
     IGSVYFFTSK VTRYDRNHKI FEYILNRLSE YFTSTSRR