HRCA_THESQ
ID HRCA_THESQ Reviewed; 338 AA.
AC B1LCI0;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=TRQ2_0076;
OS Thermotoga sp. (strain RQ2).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga;
OC unclassified Thermotoga.
OX NCBI_TaxID=126740;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RQ2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA Richardson P.;
RT "Complete sequence of Thermotoga sp. RQ2.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP000969; ACB08438.1; -; Genomic_DNA.
DR RefSeq; WP_012310306.1; NC_010483.1.
DR AlphaFoldDB; B1LCI0; -.
DR SMR; B1LCI0; -.
DR EnsemblBacteria; ACB08438; ACB08438; TRQ2_0076.
DR KEGG; trq:TRQ2_0076; -.
DR HOGENOM; CLU_050019_1_0_0; -.
DR OMA; LNWEEIE; -.
DR OrthoDB; 1510750at2; -.
DR Proteomes; UP000001687; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.390.60; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..338
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000092836"
SQ SEQUENCE 338 AA; 39392 MW; 76E2E9D60F1EBF09 CRC64;
MRRLNRKNNE ALKKLNDRQR KVLYCIVREY IENKKPVSSQ RVLEVSNIEF SSATIRNDMK
KLEYLGYIYQ PHTSAGRIPT DKGLRFYYEE MLKISKETSE ADLAVETFKS VPLADPEKIL
FLAGNLLARL TQGYVLIERP NTRDLKILRV MLIPVSEDYL IFSILTEFGV SRVTPIKTQE
RLNWEEIERQ LNFLLRGRTI GEVLMGKIES LKGSGFLRLI ESLIGETVER YLDAGLENLL
KDETLTLEDI RNLLEEVKDQ KFLESLVGEG ITVRIGREIG RKNLEKFAVF SGRYFKGESP
IGSVYFFTSK VTRYDRNHKI FEYILNRLSE YFTSTSRR