ID   HRCA_THEVB              Reviewed;         352 AA.
AC   Q8DKU4;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=tll0761;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; BA000039; BAC08312.1; -; Genomic_DNA.
DR   RefSeq; NP_681550.1; NC_004113.1.
DR   RefSeq; WP_011056606.1; NC_004113.1.
DR   AlphaFoldDB; Q8DKU4; -.
DR   SMR; Q8DKU4; -.
DR   STRING; 197221.22294482; -.
DR   EnsemblBacteria; BAC08312; BAC08312; BAC08312.
DR   KEGG; tel:tll0761; -.
DR   PATRIC; fig|197221.4.peg.800; -.
DR   eggNOG; COG1420; Bacteria.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182547"
SQ   SEQUENCE   352 AA;  39638 MW;  24F8A8E0D7B9F289 CRC64;
     MTIELSDRQK QILGATINHY IATAEPVASK AIATEYNLNV SPATVRNTML LLEKSGLLYQ
     PHTSAGRVPS DSGYRVYVDE LIQPIPDIAR KAESLLSERF IWRQQRLEVI LRQAAQLLSD
     LSGYITLITL PNALERQIRV IQLVALDSQQ VMVILVLDTY ETQSALIQLE QGEEDPELRE
     RTLQVLTNFL NHQLQGRSLV ELSAIDWQKL DLEFQTYSQQ LQALLRQLRD RYSHQGTAFV
     ISGLADLLQQ PEFSQVEQVQ MLLHLLEDQQ DQLAPLITTD SQAPSQVQIR IGSENTLAPM
     QCCTLVYSCY CYGDSPVGSI GILGPTRMPY ARIIPLVATA ADYLTEQVSC RR