ID   HRCA_THEYD              Reviewed;         348 AA.
AC   B5YH61;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=THEYE_A1760;
OS   Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87).
OC   Bacteria; Nitrospirae; Thermodesulfovibrionia; Thermodesulfovibrionales;
OC   Thermodesulfovibrionaceae; Thermodesulfovibrio.
OX   NCBI_TaxID=289376;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51303 / DSM 11347 / YP87;
RA   Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT   "The complete genome sequence of Thermodesulfovibrio yellowstonii strain
RT   ATCC 51303 / DSM 11347 / YP87.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001147; ACI21027.1; -; Genomic_DNA.
DR   RefSeq; WP_012545755.1; NC_011296.1.
DR   RefSeq; YP_002249551.1; NC_011296.1.
DR   AlphaFoldDB; B5YH61; -.
DR   SMR; B5YH61; -.
DR   STRING; 289376.THEYE_A1760; -.
DR   EnsemblBacteria; ACI21027; ACI21027; THEYE_A1760.
DR   KEGG; tye:THEYE_A1760; -.
DR   PATRIC; fig|289376.4.peg.1716; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_0; -.
DR   InParanoid; B5YH61; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000000718; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..348
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092837"
SQ   SEQUENCE   348 AA;  40445 MW;  D4039B8642839F8E CRC64;
     MRDTMLDERT KKVLYAVVES YIEKPEPVGS RYIMKKYGFD VCSATIRNIM SDLEDAGFLS
     QPHTSAGRVP TDKAYRFYVD YIFQSELFSQ SLEIKRVIEN LTKKLRKLRN NMNSLFLETT
     QSLSQATRYL GLALLPATEK TALHRVDFIK FKDDLVIAVV VNDKGIVKNK IIKVYPEITQ
     KELNSLADFV NRNYHGKTID EIRDDLIVRI KKEKIFWDRL ISKILKMCQE ALYFSREDVY
     VSGFYHIMHL PDFSDIEKLR EVAKTIQDRH LLLKLFENIS EDDEVKVIIG QENPVEEFRS
     FSIIASPYKE KDKSLGVIAL VGPKRMNYQR AIMLVNAFAR SLTRTLSD