ID   HRCA_THIDA              Reviewed;         339 AA.
AC   Q3SHA4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Tbd_2032;
OS   Thiobacillus denitrificans (strain ATCC 25259).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Thiobacillaceae; Thiobacillus.
OX   NCBI_TaxID=292415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25259;
RX   PubMed=16452431; DOI=10.1128/jb.188.4.1473-1488.2006;
RA   Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA   Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT   "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT   anaerobic bacterium Thiobacillus denitrificans.";
RL   J. Bacteriol. 188:1473-1488(2006).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000116; AAZ97985.1; -; Genomic_DNA.
DR   RefSeq; WP_011312544.1; NC_007404.1.
DR   AlphaFoldDB; Q3SHA4; -.
DR   SMR; Q3SHA4; -.
DR   STRING; 292415.Tbd_2032; -.
DR   EnsemblBacteria; AAZ97985; AAZ97985; Tbd_2032.
DR   KEGG; tbd:Tbd_2032; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000008291; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010477"
SQ   SEQUENCE   339 AA;  37104 MW;  73F3A76FB9E2FACF CRC64;
     MLNDRARILL KTLVERYISE GEPVGSRTLS KHAGLDLSPA SIRNIMSDLE EMGFVASPHT
     SAGRVPTPRG YRFFVDTLLT VRPLDQVSVN HLENSLAASD PQRLMTAAST LLSDLSQFAG
     LVMTPRRNPA FRQIEFLTLS DKRVLLIIVT MEGEVENRVI VTEQSYSAAA LTEAANYFNQ
     NFAGHSFDHV RSKLRDELGR MRDDITRLMA AAVDAGTQAL DASQDNVVVS GSRKLLDVEE
     LSSNMRSLRR LFDAFEKKTG LLQLLDQSRS AAGVQIFIGG ESELLPLDEC SLVTAPYSVD
     GVVVGTLGVV GPTRMAYERV VPIVDVTAKI LSSALSQHK