ID   HRCA_TRIV2              Reviewed;         365 AA.
AC   Q3MCK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Ava_1661;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000117; ABA21284.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3MCK2; -.
DR   SMR; Q3MCK2; -.
DR   STRING; 240292.Ava_1661; -.
DR   PRIDE; Q3MCK2; -.
DR   EnsemblBacteria; ABA21284; ABA21284; Ava_1661.
DR   KEGG; ava:Ava_1661; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_3; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..365
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010373"
SQ   SEQUENCE   365 AA;  40738 MW;  E7B01B64C3E1AC55 CRC64;
     MQVQLTNRQQ HILWATVRHY IATAEPVGSK ALVEEYDLGV SSATIRNVMG VLEKSGLLYQ
     PHTSAGRVPS DSGYRIYVDQ LITPSLRDTT RTEVLAKEVE SALQQHLQWE DWSLEILLQG
     AAQILASLSG CISLITMPQT NTASVRHLQL VQIETGRIML ILVTDSYETH SKLMDLPPAR
     SETKPDPEVI DRELQIVSNF LNSHLRGRSL LEISTLDWSQ LDREFQSYGE FLKNSVAELA
     HRSAAPAATQ IMVRGLAEVL RQPEFSQLQQ VKTIIQLLEE EQEQLWRLIF EEPELEDTHK
     SKVTVRIGAE NPLEPIRTCS LISSTYRRGG VPLGSVGVLG PTRLDYESAI AVVAAAADYL
     SEAFS