ID   HRCA_UREPA              Reviewed;         357 AA.
AC   Q9PQ68;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=UU421;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AF222894; AAF30832.1; -; Genomic_DNA.
DR   RefSeq; WP_006688647.1; NC_002162.1.
DR   AlphaFoldDB; Q9PQ68; -.
DR   SMR; Q9PQ68; -.
DR   STRING; 273119.UU421; -.
DR   EnsemblBacteria; AAF30832; AAF30832; UU421.
DR   GeneID; 29672623; -.
DR   KEGG; uur:UU421; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182554"
SQ   SEQUENCE   357 AA;  40792 MW;  2F1C3DD09028C63D CRC64;
     MKNTKTSQEQ VIELKLSDRQ KKVLKSIVDE YTISATPVSS KLLVQKEFKD QSSATIRNEM
     MFLEKNGLIE KQHISGGRVP SLKGYDFYNK NLINKNNNVS DNFKMRLHKI LSKRYSNIDE
     ILNAAVSIIN ETTQLPAVVT KTSSDELLKR IDLVKINDNS ALVLIVTSSE NILTHSIKLD
     KNTKFNDLQT CFSVLDERLV DTKLSLISSK LDLIVDIVRN KLEEVEYYFS KIVHRVFDFY
     AYKPNIDSKT YGVKYLTKHS EFEDQQKLND LLNLLEDSTI WQQIALNKKT DGLAKIMLGN
     EIGHEHLAIA TTQINLANTN HQITVVGPTR MDYAKIKALL DFLKIEIEKI LGSTNEH