ID   HRCA_UREU1              Reviewed;         357 AA.
AC   B5ZBR8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=UUR10_0466;
OS   Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=565575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33699 / Western;
RA   Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT   "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001184; ACI59910.1; -; Genomic_DNA.
DR   RefSeq; WP_004026120.1; NC_011374.1.
DR   AlphaFoldDB; B5ZBR8; -.
DR   SMR; B5ZBR8; -.
DR   STRING; 565575.UUR10_0466; -.
DR   PRIDE; B5ZBR8; -.
DR   EnsemblBacteria; ACI59910; ACI59910; UUR10_0466.
DR   GeneID; 45016009; -.
DR   KEGG; uue:UUR10_0466; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_1_0_14; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   Proteomes; UP000002018; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092838"
SQ   SEQUENCE   357 AA;  40751 MW;  BDF434700CCB6A07 CRC64;
     MKNNKILQEQ IIEPKLSDRQ KKVLKSIIDE YTITATPVSS KLLVQKEFQD QSSATIRNEM
     MLLEKFGFIE KQHISGGRVP SLKGYDFYNK NLINKNNDVS DNFKMRLHKI LSKRYSNIDE
     ILNAAVSIIN ETTQLPAVVT KSSSEELLKR IDLVKINDNS ALVLIVTSSE NILTHSIKLD
     KNTNFNDLQT CFSVLDERLV DTKLSLISSK LDLIVDIVRA KIEEAEYYFS KIVHRVFDFY
     AHKPTVNSKT YGVKYLTKHS EFEDQQKLND LLNLLEDSTI WQQIALNKKT DGLAKIMLGN
     EIGHEHLAIA TAQINLPNTN RQITVVGPTR MDYAKIKALL DFLKIEVEKI LGSSNEH