ID   HRCA_VARPS              Reviewed;         336 AA.
AC   C5CYY5;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=Vapar_4335;
OS   Variovorax paradoxus (strain S110).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=543728;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S110;
RX   PubMed=21183664; DOI=10.1128/jb.00925-10;
RA   Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G.,
RA   O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C.,
RA   Ovchinnikova G., Goodwin L., Han C.;
RT   "Complete genome sequence of the metabolically versatile plant growth-
RT   promoting endophyte, Variovorax paradoxus S110.";
RL   J. Bacteriol. 193:1183-1190(2011).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001635; ACS20946.1; -; Genomic_DNA.
DR   RefSeq; WP_015867105.1; NC_012791.1.
DR   AlphaFoldDB; C5CYY5; -.
DR   SMR; C5CYY5; -.
DR   STRING; 543728.Vapar_4335; -.
DR   EnsemblBacteria; ACS20946; ACS20946; Vapar_4335.
DR   GeneID; 45058591; -.
DR   KEGG; vap:Vapar_4335; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_4; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..336
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000202555"
SQ   SEQUENCE   336 AA;  37121 MW;  DC162C375829056F CRC64;
     MLDDRAKLLL KTLVERYIAE GQPVGSRTLS RAPGLDLSPA TIRNVMSDLE GLGLITSPHT
     SAGRIPTARG YRLFVDTMLT AQREHMNAPS HLPPDQPQKV IANAANLLSN LSQFVGVVMT
     PRRASVFKQI EFLRLSDRRL LVIIVSPDGD VQNRVIFPEA DYTQSQLVEA SNYINAHYAG
     LTIEQVRDRL QSEVEKLRGE IAALMQAAVK VSSEVLTEAQ EDDVVISGER NLLSVTDFSS
     DMGQLRRAFE LFEQKAQLMR LLDVSSKAEG VRIFIGGESQ VVPIEELSIV SANYEVDGQV
     VGTLGVIGPT RMPYERMIQI VDITSRLVSN ALSHRK