ID   HRCA_XANC5              Reviewed;         350 AA.
AC   Q3BVC0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=XCV1562;
OS   Xanthomonas campestris pv. vesicatoria (strain 85-10).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=316273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=85-10;
RX   PubMed=16237009; DOI=10.1128/jb.187.21.7254-7266.2005;
RA   Thieme F., Koebnik R., Bekel T., Berger C., Boch J., Buettner D.,
RA   Caldana C., Gaigalat L., Goesmann A., Kay S., Kirchner O., Lanz C.,
RA   Linke B., McHardy A.C., Meyer F., Mittenhuber G., Nies D.H.,
RA   Niesbach-Kloesgen U., Patschkowski T., Rueckert C., Rupp O., Schneiker S.,
RA   Schuster S.C., Vorhoelter F.J., Weber E., Puehler A., Bonas U., Bartels D.,
RA   Kaiser O.;
RT   "Insights into genome plasticity and pathogenicity of the plant pathogenic
RT   Bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete
RT   genome sequence.";
RL   J. Bacteriol. 187:7254-7266(2005).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; AM039952; CAJ23194.1; -; Genomic_DNA.
DR   RefSeq; WP_011346954.1; NZ_CP017190.1.
DR   AlphaFoldDB; Q3BVC0; -.
DR   SMR; Q3BVC0; -.
DR   STRING; 456327.BJD11_14820; -.
DR   EnsemblBacteria; CAJ23194; CAJ23194; XCV1562.
DR   KEGG; xcv:XCV1562; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_6; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000007069; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..350
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000010478"
SQ   SEQUENCE   350 AA;  38230 MW;  EE9346CE50F4CB0A CRC64;
     MRASQSPMLD PRARQLLRTL IARYIRDGEP VGSKTLAQHA GLDVSPATIR NILADLEDVG
     LLSSPHTSAG RVPTAHGYRV FVDSLVQMQP PGEEEVRRLR AELASGNGTQ SLLGSASQML
     SAMSHFVGVV SAPRREQFAF RHIDFVALDA RRVLAILVFA DNEVQNRVIE PRRAYEPAEL
     ERVANYLNAQ FAGRALADIR ACLLRELRMA KSEMEQLLAH SVDLASEALV PADAEDMVMA
     GQTRLMGVQD LSDLDRLREL FEAFASKREI LQLLERTIQA PGVRIFIGEE TGMVSLEDVS
     LVTAPYAANG QVLGVLGVIG PKRMAYDRLI PLVQTAADVL GAAMESPGTR