ID   HRCA_XANCP              Reviewed;         350 AA.
AC   Q8PAL1; Q93TY0;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=XCC1472;
OS   Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB
OS   528 / LMG 568 / P 25).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=190485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11479711; DOI=10.1007/s002030100302;
RA   Weng S.-F., Tai P.-M., Yang C.-H., Wu C.-D., Tsai W.-J., Lin J.-W.,
RA   Tseng Y.-H.;
RT   "Characterization of stress-responsive genes, hrcA-grpE-dnaK-dnaJ, from
RT   phytopathogenic Xanthomonas campestris.";
RL   Arch. Microbiol. 176:121-128(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25;
RX   PubMed=12024217; DOI=10.1038/417459a;
RA   da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R.,
RA   Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr.,
RA   Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G.,
RA   Cannavan F., Cardozo J., Chambergo F., Ciapina L.P., Cicarelli R.M.B.,
RA   Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B.,
RA   Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F.,
RA   Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T.,
RA   Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A.,
RA   Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J.,
RA   Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M.,
RA   Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A.,
RA   Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A.,
RA   Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M.,
RA   Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.;
RT   "Comparison of the genomes of two Xanthomonas pathogens with differing host
RT   specificities.";
RL   Nature 417:459-463(2002).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM40768.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF302775; AAG53934.2; -; Genomic_DNA.
DR   EMBL; AE008922; AAM40768.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_636844.1; NC_003902.1.
DR   AlphaFoldDB; Q8PAL1; -.
DR   SMR; Q8PAL1; -.
DR   STRING; 340.xcc-b100_2801; -.
DR   EnsemblBacteria; AAM40768; AAM40768; XCC1472.
DR   KEGG; xcc:XCC1472; -.
DR   PATRIC; fig|190485.4.peg.1576; -.
DR   eggNOG; COG1420; Bacteria.
DR   HOGENOM; CLU_050019_0_0_6; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001010; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Stress response; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..350
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_0000182556"
FT   CONFLICT        234..236
FT                   /note="DDG -> ADD (in Ref. 1; AAG53934)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   350 AA;  38290 MW;  E008DFD0E298445B CRC64;
     MRASQSPMLD PRARHLLRTL IARYIRDGEP VGSKTLAQHA GLDVSPATIR NILADLEDIG
     LLSSPHTSAG RVPTAHGYRV FVDSLVQMQP PGEEEVRRLR AELASSNGTQ SLLGSASQML
     SAMSHFVGVV SAPRREQFAF RHIDFVPLDA RRVLAILVFA DNEVQNRVIE PRRAYEPAEL
     ERVANYLNAQ FAGRALSDIR ASLLRELRLA KNEMEQLLAH SVDLASEALV PADDDGMVMA
     GQTRLMGVQD LSDLDRLREL FEAFASKREI LQLLERTIQA PGVRIFIGEE TGMVSLDDVS
     LVTAPYTAGG QVLGVLGVIG PKRMAYDRVI PLVQTAAQML GAAMEPPGTR