ID   HRCA_XYLF2              Reviewed;         349 AA.
AC   B2I6F8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=XfasM23_1457;
OS   Xylella fastidiosa (strain M23).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M23;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP001011; ACB92868.1; -; Genomic_DNA.
DR   RefSeq; WP_004091048.1; NC_010577.1.
DR   AlphaFoldDB; B2I6F8; -.
DR   SMR; B2I6F8; -.
DR   EnsemblBacteria; ACB92868; ACB92868; XfasM23_1457.
DR   GeneID; 58016896; -.
DR   KEGG; xfn:XfasM23_1457; -.
DR   HOGENOM; CLU_050019_0_0_6; -.
DR   OMA; DYPGTMG; -.
DR   Proteomes; UP000001698; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..349
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092839"
SQ   SEQUENCE   349 AA;  38645 MW;  8ADE8CF24CAD2B52 CRC64;
     MCASFSPTLD SRSRQLLRTL ISCYIQNGEP IGSKTLAQQA GLDISPATIR NILADLEELG
     LLNSPHTSAG RVPTAHGYRM FVDSLVQMQP PSEDDIRRLR VEMTGGGTQT LLGSASEILS
     AMTHFVGVVS APRREQFVFR HIDFVPLDAR QIMAILIFAD NEVQNRVIEP RRVYEPGELE
     RVSNYLNAHF IGRTLADIRT TVLCELRKAK DEMEQLLAHS LDLASQMLVP NDSEDIVVTG
     QTRLMALQDL SDMDRLRELF EIFASKREIL QLLERTIDAP GVRIFIGEET GMVSMEDISL
     VTAPYAAHGQ VLGVLGVIGP KRMAYDRVIP LVQVVAQVLG TALEPPTMP