ID   HRCA_XYLFM              Reviewed;         349 AA.
AC   B0U3K0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN   OrderedLocusNames=Xfasm12_1514;
OS   Xylella fastidiosa (strain M12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M12;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC       dnaJ and groELS operons). Prevents heat-shock induction of these
CC       operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00081}.
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DR   EMBL; CP000941; ACA12429.1; -; Genomic_DNA.
DR   RefSeq; WP_004085848.1; NC_010513.1.
DR   AlphaFoldDB; B0U3K0; -.
DR   SMR; B0U3K0; -.
DR   KEGG; xfm:Xfasm12_1514; -.
DR   HOGENOM; CLU_050019_0_0_6; -.
DR   OMA; DYPGTMG; -.
DR   OrthoDB; 1510750at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   Pfam; PF03444; HrcA_DNA-bdg; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
KW   Repressor; Stress response; Transcription; Transcription regulation.
FT   CHAIN           1..349
FT                   /note="Heat-inducible transcription repressor HrcA"
FT                   /id="PRO_1000092840"
SQ   SEQUENCE   349 AA;  38597 MW;  1D661A35F1AE0F96 CRC64;
     MCASFSPTLD SRSRQLLRTL ISCYIQNGEP VGSKTLAQQA GLDISPATIR NILADLEELG
     LLNSPHTSAG RVPTAHGYRM FVDSLVQMQP PSEDDIRRLR VEMAGGGTQA LLGNASEILS
     AMTHFVGVVS APRREQFVFR HIDFVPLDAR QIMAILIFAD NEVQNRVIEP RRVYEPGELE
     RVSNYLNAHF IGRTLADIRT TVLCELRKAK DEMEQLLAHS LDLASQMLVP NDSEDIVVTG
     QTRLMALQDL SDMDRLRELF EIFASKREIL QLLERTINAP GVRIFIGEET GMVSMEDISL
     VTAPYAAHGQ VLGVLGVIGP KRMAYDRVIP LVQVVAQVLG TALEPPTMP