HRCA_ZYMMO
ID HRCA_ZYMMO Reviewed; 345 AA.
AC Q5NRL5;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=ZMO0015;
OS Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Zymomonadaceae; Zymomonas.
OX NCBI_TaxID=264203;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RX PubMed=15592456; DOI=10.1038/nbt1045;
RA Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA Kang H.S.;
RT "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT ZM4.";
RL Nat. Biotechnol. 23:63-68(2005).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AE008692; AAV88639.1; -; Genomic_DNA.
DR RefSeq; WP_011240003.1; NZ_CP035711.1.
DR AlphaFoldDB; Q5NRL5; -.
DR SMR; Q5NRL5; -.
DR STRING; 264203.ZMO0015; -.
DR EnsemblBacteria; AAV88639; AAV88639; ZMO0015.
DR GeneID; 58025925; -.
DR KEGG; zmo:ZMO0015; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_5; -.
DR OMA; DYPGTMG; -.
DR OrthoDB; 1510750at2; -.
DR Proteomes; UP000001173; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR34824; PTHR34824; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00331; hrcA; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..345
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182559"
SQ SEQUENCE 345 AA; 37327 MW; 321B631D841942E6 CRC64;
MSSIPVIELS SRAREIFQLV VESYLGSGLP VGSKTLARQG VNLSPASIRY VLQELETKGL
LLSPHISAGR MPTELGLRLF VNGMMQLSEP SEEERSAIEA DVIRGHSPKE RLVNATTTLS
GLSACAGLVL VPKQELVLKQ LGFVVLDDNR ALAIIVGSDG SVENRVIELS SGFPASALTE
ASNYINAHFS GYSFSEAKKR LFSQIDLERS ELDSAASDLI KRGLAVWSED SRKRPVLIVR
GQSHLLQDAS EDLDRAKQLL EELEDKKEIA GLLEKVSESD AAQIFIGSEN KLFSLSGSSV
IASPYHGEDG HMVGVVAVIG PTRLNYGRIV PMVDFTAKTL SRIIA