HRCT1_HUMAN
ID HRCT1_HUMAN Reviewed; 115 AA.
AC Q6UXD1; B7ZBJ1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Histidine-rich carboxyl terminus protein 1;
GN Name=HRCT1; ORFNames=UNQ338/PRO537;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AY358408; AAQ88774.1; -; mRNA.
DR EMBL; AL135841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35012.1; -.
DR RefSeq; NP_001034881.1; NM_001039792.1.
DR AlphaFoldDB; Q6UXD1; -.
DR BioGRID; 571767; 1.
DR STRING; 9606.ENSP00000346283; -.
DR BioMuta; HRCT1; -.
DR DMDM; 74738206; -.
DR PaxDb; Q6UXD1; -.
DR PeptideAtlas; Q6UXD1; -.
DR PRIDE; Q6UXD1; -.
DR ProteomicsDB; 67591; -.
DR Antibodypedia; 78136; 4 antibodies from 4 providers.
DR DNASU; 646962; -.
DR Ensembl; ENST00000354323.3; ENSP00000346283.2; ENSG00000196196.3.
DR GeneID; 646962; -.
DR KEGG; hsa:646962; -.
DR MANE-Select; ENST00000354323.3; ENSP00000346283.2; NM_001039792.2; NP_001034881.1.
DR UCSC; uc003zyr.1; human.
DR CTD; 646962; -.
DR DisGeNET; 646962; -.
DR GeneCards; HRCT1; -.
DR HGNC; HGNC:33872; HRCT1.
DR HPA; ENSG00000196196; Tissue enhanced (adipose tissue, breast).
DR neXtProt; NX_Q6UXD1; -.
DR OpenTargets; ENSG00000196196; -.
DR PharmGKB; PA164720718; -.
DR VEuPathDB; HostDB:ENSG00000196196; -.
DR eggNOG; ENOG502SX6E; Eukaryota.
DR GeneTree; ENSGT00510000049544; -.
DR HOGENOM; CLU_177134_0_0_1; -.
DR InParanoid; Q6UXD1; -.
DR OMA; ATCLFHG; -.
DR OrthoDB; 1626268at2759; -.
DR PhylomeDB; Q6UXD1; -.
DR PathwayCommons; Q6UXD1; -.
DR BioGRID-ORCS; 646962; 13 hits in 1060 CRISPR screens.
DR GenomeRNAi; 646962; -.
DR Pharos; Q6UXD1; Tdark.
DR PRO; PR:Q6UXD1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q6UXD1; protein.
DR Bgee; ENSG00000196196; Expressed in mucosa of transverse colon and 118 other tissues.
DR Genevisible; Q6UXD1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031506; HRCT1.
DR PANTHER; PTHR23009; PTHR23009; 1.
DR Pfam; PF15758; HRCT1; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..115
FT /note="Histidine-rich carboxyl terminus protein 1"
FT /id="PRO_0000317638"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 86..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 115 AA; 13183 MW; 8EE498C8AA1DE8D6 CRC64;
MLGLLGSTAL VGWITGAAVA VLLLLLLLAT CLFHGRQDCD VERNRTAAGG NRVRRAQPWP
FRRRGHLGIF HHHRHPGHVS HVPNVGLHHH HHPRHTPHHL HHHHHPHRHH PRHAR
