HRD3B_ARATH
ID HRD3B_ARATH Reviewed; 604 AA.
AC Q9C6B6; Q9FX49;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=ERAD-associated E3 ubiquitin-protein ligase component HRD3B {ECO:0000305};
DE AltName: Full=AtSel1B {ECO:0000305};
DE Flags: Precursor;
GN Name=HRD3B {ECO:0000305};
GN OrderedLocusNames=At1g73570 {ECO:0000312|Araport:AT1G73570};
GN ORFNames=F6D5.4 {ECO:0000312|EMBL:AAG51809.1},
GN T9L24.27 {ECO:0000312|EMBL:AAG30966.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in the endoplasmic reticulum (ER) quality
CC control system called ER-associated degradation (ERAD).
CC {ECO:0000250|UniProtKB:Q9LM25}.
CC -!- SIMILARITY: Belongs to the sel-1 family. {ECO:0000305}.
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DR EMBL; AC012396; AAG30966.1; -; Genomic_DNA.
DR EMBL; AC079676; AAG51809.1; -; Genomic_DNA.
DR EMBL; CP002684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; E96762; E96762.
DR AlphaFoldDB; Q9C6B6; -.
DR SMR; Q9C6B6; -.
DR STRING; 3702.AT1G73570.1; -.
DR TCDB; 3.A.16.1.5; the endoplasmic reticular retrotranslocon (er-rt) family.
DR PaxDb; Q9C6B6; -.
DR PRIDE; Q9C6B6; -.
DR Araport; AT1G73570; -.
DR TAIR; locus:2035047; AT1G73570.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_007931_4_0_1; -.
DR InParanoid; Q9C6B6; -.
DR PhylomeDB; Q9C6B6; -.
DR PRO; PR:Q9C6B6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6B6; baseline and differential.
DR Genevisible; Q9C6B6; AT.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR044623; HRD3.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR45084; PTHR45084; 2.
DR Pfam; PF08238; Sel1; 7.
DR SMART; SM00671; SEL1; 7.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Repeat; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..604
FT /note="ERAD-associated E3 ubiquitin-protein ligase
FT component HRD3B"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431274"
FT REPEAT 125..160
FT /note="Sel1-like 1"
FT /evidence="ECO:0000255"
FT REPEAT 244..274
FT /note="Sel1-like 2"
FT /evidence="ECO:0000255"
FT REPEAT 279..307
FT /note="Sel1-like 3"
FT /evidence="ECO:0000255"
FT REPEAT 311..344
FT /note="Sel1-like 4"
FT /evidence="ECO:0000255"
FT REPEAT 346..380
FT /note="Sel1-like 5"
FT /evidence="ECO:0000255"
FT REPEAT 464..492
FT /note="Sel1-like 6"
FT /evidence="ECO:0000255"
FT REPEAT 498..528
FT /note="Sel1-like 7"
FT /evidence="ECO:0000255"
FT REGION 48..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 604 AA; 67761 MW; 973AFD4E38D7EBA6 CRC64;
MRVSGQSIIA ISLFTLSLYI HRVQARPFVL VLSNEDLNGG FNDNGAYESS DFDEFGESEP
KSEEELDPGS WRRIFETNES TVHASASPQY YSGLHKILSA ASEGNTTLME EAVSEIDSSA
SSGDPHAQSV MGFVYGIGMM RETSRSKSIL HHHFAAAGGN MQSKMALAFR YLRQNMYDKA
VELYAELAET AVNSFLISKD SPMAEPVRIH IGTEENKDAL RKSRGEEDED FQILEYQAEK
GNSVAMHKIG LFYYFGLRGL RRDHAKALYW FSKAEFNGLG YLYVKGYGVD KRNYTKAREY
FEMAANNEDP SGHYNLGVLY LKGTGVKKDV RHATKYFFVA ANAGQPKAFY QLAKMFHTGV
GLTKNLEMAT TFYKLVAERG PWSSLSRWAL EAYLKGDVGK AFILYSRMSE LGYEVAQSNA
AWIVDKYGER SMCMGVYGFC TDKERHDRAH SLWWRASEQG NEHAALLIGD AYYYGRGTER
DFVRAAEAYM YAKSQSNAQA MFNLGYMHEH GEGLPFDLHL AKRYYDQALQ SDTAAKLPVT
LALASVWVRR NYADTALVQV LNSLPEVHQK VVEWVENGML EEVVLDPVGA NVAQPLAAPV
AFPQ
