HRD3_ORYSJ
ID HRD3_ORYSJ Reviewed; 694 AA.
AC Q10NT7; A0A0N7KGY9;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=ERAD-associated E3 ubiquitin-protein ligase component HRD3 {ECO:0000305};
DE AltName: Full=OsSel1 {ECO:0000305};
DE Flags: Precursor;
GN Name=HRD3 {ECO:0000305};
GN OrderedLocusNames=Os03g0259300 {ECO:0000312|EMBL:BAF11525.1},
GN LOC_Os03g15350 {ECO:0000312|EMBL:ABF95069.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Component of the endoplasmic reticulum (ER) quality control
CC system called ER-associated degradation (ERAD) and involved in
CC ubiquitin-dependent degradation of misfolded endoplasmic reticulum
CC proteins. Functions as an ERAD substrate-recruiting factor that
CC recognizes misfolded proteins for the HRD1 E3 ubiquitin ligase complex.
CC {ECO:0000250|UniProtKB:Q9LM25}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sel-1 family. {ECO:0000305}.
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DR EMBL; DP000009; ABF95069.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11525.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS83345.1; -; Genomic_DNA.
DR EMBL; AK063394; BAG88680.1; -; mRNA.
DR RefSeq; XP_015630912.1; XM_015775426.1.
DR AlphaFoldDB; Q10NT7; -.
DR SMR; Q10NT7; -.
DR STRING; 4530.OS03T0259300-01; -.
DR PaxDb; Q10NT7; -.
DR PRIDE; Q10NT7; -.
DR EnsemblPlants; Os03t0259300-01; Os03t0259300-01; Os03g0259300.
DR GeneID; 4332310; -.
DR Gramene; Os03t0259300-01; Os03t0259300-01; Os03g0259300.
DR KEGG; osa:4332310; -.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_007931_4_0_1; -.
DR InParanoid; Q10NT7; -.
DR OMA; DMLAKPR; -.
DR OrthoDB; 357553at2759; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR Genevisible; Q10NT7; OS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR044623; HRD3.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011716; TPR-3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR45084; PTHR45084; 1.
DR Pfam; PF08238; Sel1; 9.
DR Pfam; PF07720; TPR_3; 1.
DR SMART; SM00671; SEL1; 8.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..43
FT /evidence="ECO:0000255"
FT CHAIN 44..694
FT /note="ERAD-associated E3 ubiquitin-protein ligase
FT component HRD3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431275"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 157..190
FT /note="Sel1-like 1"
FT /evidence="ECO:0000255"
FT REPEAT 275..309
FT /note="Sel1-like 2"
FT /evidence="ECO:0000255"
FT REPEAT 311..343
FT /note="Sel1-like 3"
FT /evidence="ECO:0000255"
FT REPEAT 348..380
FT /note="Sel1-like 4"
FT /evidence="ECO:0000255"
FT REPEAT 386..417
FT /note="Sel1-like 5"
FT /evidence="ECO:0000255"
FT REPEAT 419..453
FT /note="Sel1-like 6"
FT /evidence="ECO:0000255"
FT REPEAT 537..568
FT /note="Sel1-like 7"
FT /evidence="ECO:0000255"
FT REPEAT 571..602
FT /note="Sel1-like 8"
FT /evidence="ECO:0000255"
FT REGION 61..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 366
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 694 AA; 76573 MW; 472DDCB9F82938A1 CRC64;
MQNRRRSRPV VPTPMARVRH RHLLLLVAAV AAAASALLPC ASAVRPFVLV LSRDDFLKDT
AGAHPSLPSA DADSDEWDDF DDESPATDPL LSPSSWVPLL DPASASPSGD EPDSPSDALF
VAGVRAMLSA ASAGDDAAFA TAAAQIEAAA TGGHPGAQSA LAFLSGAGMT RPASRSRAFL
LHKFAADAGD LQSKMALAYS FFRQEMYEEA VTLYAELAEA ALTSSLISKE PPVIEPVRLH
SGTEENKEAL RKSRGEDDED FQITEYQAQR GNTVAMHKLG LLYYYGLRGV RRDYGKAYHW
FSKAVEKGDT RAMELLGEIY ARGAGVERNY TEAYKWLTLA AKQQQYSAYN GLGYLYVKGY
GVEKKNLTKA KEFFEIAAEH KEHGGYYNLG VLYLKGIGVK RDVMTACNFF LRAVNAGQPK
AIYQVAKLFQ KGVGLKRNLQ MAAVMYKSVA ERGPWSSLSR WALESYLKGD IGKALLLYSR
MADLGYEVAQ SNAAWILDRY GDESICMGES GFCTDMERHL RAHALWWQAS EQGNEHAALL
IGDAYYYGRG VGRDYERAAE AYMHAQSQSN AQAMFNLGYM HEHGHGLPLD LHLAKRYYDQ
AVEVDPAAKL PVMLALTSLW IRKNYDGSFL VHFIDSLPEV YPVVEEWVED VLMDEGNATI
FTLFACLVTV LYLRERQRRQ AAAANPQQPD GAPI
