ID   HRDC_STRCO              Reviewed;         339 AA.
AC   P18184;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 140.
DE   RecName: Full=RNA polymerase principal sigma factor HrdC;
GN   Name=hrdC; OrderedLocusNames=SCO0895; ORFNames=SCM1.28c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=1944221; DOI=10.1007/bf00267453;
RA   Tanaka K., Shiina T., Takahashi H.;
RT   "Nucleotide sequence of genes hrdA, hrdC, and hrdD from Streptomyces
RT   coelicolor A3(2) having similarity to rpoD genes.";
RL   Mol. Gen. Genet. 229:334-340(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-185.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=3194753; DOI=10.1126/science.3194753;
RA   Tanaka K., Shiina T., Takahashi H.;
RT   "Multiple principal sigma factor homologs in eubacteria: identification of
RT   the 'rpoD box'.";
RL   Science 242:1040-1042(1988).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; X52981; CAA37173.1; -; Genomic_DNA.
DR   EMBL; AL939107; CAB62686.1; -; Genomic_DNA.
DR   PIR; S17930; S17930.
DR   RefSeq; NP_625194.1; NC_003888.3.
DR   RefSeq; WP_003977963.1; NZ_VNID01000004.1.
DR   AlphaFoldDB; P18184; -.
DR   SMR; P18184; -.
DR   STRING; 100226.SCO0895; -.
DR   GeneID; 1096318; -.
DR   KEGG; sco:SCO0895; -.
DR   PATRIC; fig|100226.15.peg.887; -.
DR   eggNOG; COG0568; Bacteria.
DR   HOGENOM; CLU_014793_3_5_11; -.
DR   InParanoid; P18184; -.
DR   OMA; HEQLGRW; -.
DR   PhylomeDB; P18184; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..339
FT                   /note="RNA polymerase principal sigma factor HrdC"
FT                   /id="PRO_0000093993"
FT   DNA_BIND        300..319
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           130..143
FT                   /note="Polymerase core binding"
FT   COMPBIAS        9..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        173
FT                   /note="H -> HI (in Ref. 3; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   339 AA;  38173 MW;  36B875EF5B047489 CRC64;
     MAPTARTPTA RTRDDRRATT RTARLRTRIP EPDEEPDLLG QYLTQIGATP LLTAEDEVRL
     ATRIEAGVRA REELETADTG EPAPTPRRRR TLEETVHDGQ EAKDHMVRAN LRLVVSMAKR
     HAHRGLPLLD VIQEGNLGLI RAVEKFDHTK GFKFSTYATW WIRQAIERGL ATHARTVRLP
     VHVVEQLQKL AKVERKLRAG LDREPTTEEV AAESGIDVDK VVWLRRVGRD AVSLDTPVDE
     TGDTVVGDLI PDTEVLRAPE VAEFQALAAE LREAVGTLAP RESLILSLRY GLHDGRPRTL
     QQVAQHVGLT RERVRQLEKE SLAHLRAPEN RERLLDWAS