ID   HRDD_STRCO              Reviewed;         332 AA.
AC   P18249; Q9KYU3;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 2.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=RNA polymerase principal sigma factor HrdD;
GN   Name=hrdD; OrderedLocusNames=SCO3202; ORFNames=SCE22.19c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=1944221; DOI=10.1007/bf00267453;
RA   Tanaka K., Shiina T., Takahashi H.;
RT   "Nucleotide sequence of genes hrdA, hrdC, and hrdD from Streptomyces
RT   coelicolor A3(2) having similarity to rpoD genes.";
RL   Mol. Gen. Genet. 229:334-340(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-179.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=3194753; DOI=10.1126/science.3194753;
RA   Tanaka K., Shiina T., Takahashi H.;
RT   "Multiple principal sigma factor homologs in eubacteria: identification of
RT   the 'rpoD box'.";
RL   Science 242:1040-1042(1988).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; X52982; CAA37174.1; -; Genomic_DNA.
DR   EMBL; AL939115; CAB90986.1; -; Genomic_DNA.
DR   PIR; D40116; D40116.
DR   PIR; S17931; S11714.
DR   RefSeq; NP_627416.1; NC_003888.3.
DR   RefSeq; WP_003975615.1; NZ_VNID01000013.1.
DR   AlphaFoldDB; P18249; -.
DR   SMR; P18249; -.
DR   STRING; 100226.SCO3202; -.
DR   GeneID; 1098636; -.
DR   KEGG; sco:SCO3202; -.
DR   PATRIC; fig|100226.15.peg.3262; -.
DR   eggNOG; COG0568; Bacteria.
DR   HOGENOM; CLU_014793_3_4_11; -.
DR   InParanoid; P18249; -.
DR   OMA; RRVQREF; -.
DR   PhylomeDB; P18249; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..332
FT                   /note="RNA polymerase principal sigma factor HrdD"
FT                   /id="PRO_0000093994"
FT   DNA_BIND        294..313
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           124..137
FT                   /note="Polymerase core binding"
FT   CONFLICT        148
FT                   /note="F -> I (in Ref. 3; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="Q -> H (in Ref. 3; no nucleotide entry)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="T -> H (in Ref. 1; CAA37174)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   332 AA;  37155 MW;  BEAC010BBC0C442B CRC64;
     MATRAVARRK SAAGETSGSA TSVRANGGEL ADRDLVGMYL DEIARTPLLD AAKEVELSQT
     IEAGVFARQV LEGYEETGAD ATREELQALI DESERAKDVF IRSNLRLVVA VARRYPRSGL
     PLLDLIQEGN AGLVRAVEKF DYRKGFKFST YATWWIRQAI TRSIADQSRT IRLPVHLVEE
     LGRIRRVQRE FNREHGREPE PAEIAAELGS TPERVTDVLD WARDPVSLNM SVDDEGETQF
     GDLLEDTSAV SPEQSVLTLL RSEELDDLIG RLDPRTASII KMRYGIDDGR ERTLTEVGKE
     HGLTRERIRQ IEKHALLELK KLARDTGFEA AA