ID   HRDD_STRGR              Reviewed;         332 AA.
AC   Q59914;
DT   24-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=RNA polymerase principal sigma factor HrdD;
GN   Name=hrdD;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IMRU 3570;
RX   PubMed=7883183; DOI=10.1016/0378-1119(94)00759-l;
RA   Marcos A.T., Diez B., Gutierrez S., Fernandez F.J., Oguiza J.A.,
RA   Martin J.F.;
RT   "Three genes hrdB, hrdD and hrdT of Streptomyces griseus IMRU 3570,
RT   encoding sigma factor-like proteins, are differentially expressed under
RT   specific nutritional conditions.";
RL   Gene 153:41-48(1995).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; X79980; CAA56305.1; -; Genomic_DNA.
DR   PIR; S49185; S49185.
DR   AlphaFoldDB; Q59914; -.
DR   SMR; Q59914; -.
DR   STRING; 1911.GCA_001715295_05820; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..332
FT                   /note="RNA polymerase principal sigma factor HrdD"
FT                   /id="PRO_0000093995"
FT   DNA_BIND        294..313
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           124..137
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   332 AA;  36769 MW;  A5807F38CEDB0838 CRC64;
     MATRAVARRQ PAASGETGAA GSVRATGEIA DRDLVGMYLD EIARTPLLDA AKEVELSQTI
     EAGVYAGKIL DGEVDSDSAG ASREELEALV AEGERAKDVF IRSNLRLVVA VARRYPRSGL
     PLLDLIQEGN AGLVRAVEKF DYAKGFKFST YATWWIRQAI TRSIADQSRT IRLPVHLVEE
     LGRIRRVQRE FNRENGRDPE PAEIAAELSS TPERVTDVLD WARDPVSLNM SVDDEGETQF
     GDLLEDTSAV SPEQSVLTLL RSEELDDLIG QLDDRTASII KMRYGIEDGR ERTLTEVGKQ
     HGLTRERIRQ IEKHALLELK RMAHDTGFDA AA