ID   HRDD_STRVF              Reviewed;         332 AA.
AC   Q60012;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=RNA polymerase principal sigma factor HrdD;
GN   Name=hrdD;
OS   Streptomyces viridifaciens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=48665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MG456-hF10;
RA   Li W., Parry R.J.;
RT   "Nucleotide sequence of the hrdD gene from the valanimycin producer,
RT   Streptomyces viridifaciens MG456-hF10.";
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U60418; AAB03580.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q60012; -.
DR   SMR; Q60012; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 2.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..332
FT                   /note="RNA polymerase principal sigma factor HrdD"
FT                   /id="PRO_0000093996"
FT   DNA_BIND        294..313
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           124..137
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   332 AA;  37100 MW;  E214BC68C57809AE CRC64;
     MATRAVARRQ SATGETADSA SSVRAHGGEI ADRDLVGMYL DEIARTPLLD AAKEVELSQT
     IEAGVFAQQV LDGEEESRTD ATREELQALV DAGERAKDVF IRSNLRLVVA VARRYPRSGL
     PLLDLIQEGN AGLVRAVEKF DYRKGFKFST YATWWIRQAI TRSIADQSRT IRLPVHLVEE
     LGRIRRVQRE FNREHGRDPE PAEVAAELGS TPERVIDVLD WARDPVSLNM AVDDAGETQF
     GDLLEDTSAV SPEQSVLTLL RSEELDDLIG RLDQRTASII KMRYGIDDGR ERTLTEVGKE
     HGLTRERIRQ IEKHALLELK KLARDTGFDA AA