ID   HRG1A_DANRE             Reviewed;         144 AA.
AC   Q7T3B2; A8KBS4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Heme transporter hrg1-A;
DE            Short=zHRG-1;
DE   AltName: Full=Heme-responsive gene 1 protein homolog A;
DE            Short=HRG-1A;
DE   AltName: Full=Solute carrier family 48 member 1-B;
GN   Name=slc48a1b; Synonyms=hrg1a; ORFNames=zgc:63994;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=18418376; DOI=10.1038/nature06934;
RA   Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA   Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT   "Haem homeostasis is regulated by the conserved and concerted functions of
RT   HRG-1 proteins.";
RL   Nature 453:1127-1131(2008).
CC   -!- FUNCTION: Heme transporter that regulates intracellular heme
CC       availability through the endosomal or lysosomal compartment.
CC       {ECO:0000269|PubMed:18418376}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed throughout the embryo, including the
CC       central nervous system. {ECO:0000269|PubMed:18418376}.
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; BC053186; AAH53186.1; -; mRNA.
DR   EMBL; BC154226; AAI54227.1; -; mRNA.
DR   RefSeq; NP_956300.1; NM_200006.1.
DR   AlphaFoldDB; Q7T3B2; -.
DR   STRING; 7955.ENSDARP00000035010; -.
DR   PaxDb; Q7T3B2; -.
DR   Ensembl; ENSDART00000029930; ENSDARP00000035010; ENSDARG00000026109.
DR   GeneID; 792763; -.
DR   KEGG; dre:792763; -.
DR   CTD; 792763; -.
DR   ZFIN; ZDB-GENE-030131-8226; slc48a1b.
DR   eggNOG; ENOG502S0AI; Eukaryota.
DR   GeneTree; ENSGT00390000002307; -.
DR   HOGENOM; CLU_148774_0_0_1; -.
DR   InParanoid; Q7T3B2; -.
DR   OMA; HWRTWLK; -.
DR   OrthoDB; 1396314at2759; -.
DR   PhylomeDB; Q7T3B2; -.
DR   TreeFam; TF332621; -.
DR   PRO; PR:Q7T3B2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000026109; Expressed in early embryo and 25 other tissues.
DR   ExpressionAtlas; Q7T3B2; baseline.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IDA:ZFIN.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IDA:ZFIN.
DR   GO; GO:0048821; P:erythrocyte development; IMP:ZFIN.
DR   GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 2.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..144
FT                   /note="Heme transporter hrg1-A"
FT                   /id="PRO_0000348579"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           140..141
FT                   /note="Di-leucine motif"
FT   CONFLICT        8
FT                   /note="I -> T (in Ref. 1; AAI54227)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   144 AA;  16627 MW;  9F58A07472D8EE74 CRC64;
     MAFNKTYIRV GYSCMGMLVG FSAFLVWNIA YKQPWTAAMG GLSGVLALWA LVTHIMYIQD
     YWRTWLKGLK FFMAMGVIFS VLSIVAFISF LCVAISRQQS LTDPTSLYLS CVWSFMSLKW
     SFLLTLYSHR YRKEFADISI LNDF