ID   HRG1A_XENLA             Reviewed;         145 AA.
AC   Q63ZL3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Heme transporter hrg1-A;
DE   AltName: Full=Heme-responsive gene 1 protein homolog A;
DE            Short=HRG-1A;
DE   AltName: Full=Solute carrier family 48 member 1-A;
GN   Name=slc48a1-a; Synonyms=hrg1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Heme transporter that regulates intracellular heme
CC       availability through the endosomal or lysosomal compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; BC082899; AAH82899.1; -; mRNA.
DR   RefSeq; NP_001088117.1; NM_001094648.1.
DR   AlphaFoldDB; Q63ZL3; -.
DR   DNASU; 494820; -.
DR   GeneID; 494820; -.
DR   KEGG; xla:494820; -.
DR   CTD; 494820; -.
DR   Xenbase; XB-GENE-5804136; slc48a1.L.
DR   OMA; SCVWSVM; -.
DR   OrthoDB; 1396314at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 494820; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 2.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..145
FT                   /note="Heme transporter hrg1-A"
FT                   /id="PRO_0000348581"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           141..142
FT                   /note="Di-leucine motif"
SQ   SEQUENCE   145 AA;  16619 MW;  D685DC647664AB15 CRC64;
     MAVTRQLWIR IIYAAVGTLF GLSAFLVWNV AFVQPWTAAM GGLSGVLALW ALITHIMYVQ
     DFWRTWLKGL RFFLCIGVLF LVLALVAFIT FLAVAISEKQ SISDPKSLYL SCVWSFMSMK
     WAFLLSLYSH RYRKEFADIS ILSDF