HRG1B_DANRE
ID HRG1B_DANRE Reviewed; 144 AA.
AC Q6ZM28; Q6DH36;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Heme transporter hrg1-B;
DE AltName: Full=Heme-responsive gene 1 protein homolog B;
DE Short=HRG-1B;
DE AltName: Full=Solute carrier family 48 member 1-A;
GN Name=slc48a1a; Synonyms=hrg1b; ORFNames=si:ch211-226m16.1, zgc:92662;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Heme transporter that regulates intracellular heme
CC availability through the endosomal or lysosomal compartment.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR EMBL; AL929087; CAE51049.2; -; Genomic_DNA.
DR EMBL; CR293512; CAE51049.2; JOINED; Genomic_DNA.
DR EMBL; BC076146; AAH76146.1; -; mRNA.
DR RefSeq; NP_001002424.1; NM_001002424.2.
DR AlphaFoldDB; Q6ZM28; -.
DR STRING; 7955.ENSDARP00000033200; -.
DR PaxDb; Q6ZM28; -.
DR Ensembl; ENSDART00000031638; ENSDARP00000033200; ENSDARG00000026907.
DR GeneID; 436697; -.
DR KEGG; dre:436697; -.
DR CTD; 436697; -.
DR ZFIN; ZDB-GENE-040718-121; slc48a1a.
DR eggNOG; ENOG502S0AI; Eukaryota.
DR GeneTree; ENSGT00390000002307; -.
DR HOGENOM; CLU_148774_0_0_1; -.
DR InParanoid; Q6ZM28; -.
DR OMA; YLSCIWS; -.
DR OrthoDB; 1396314at2759; -.
DR PhylomeDB; Q6ZM28; -.
DR TreeFam; TF332621; -.
DR PRO; PR:Q6ZM28; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 23.
DR Bgee; ENSDARG00000026907; Expressed in retina and 19 other tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IDA:ZFIN.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IDA:ZFIN.
DR GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR Pfam; PF16954; HRG; 2.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..144
FT /note="Heme transporter hrg1-B"
FT /id="PRO_0000348580"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 140..141
FT /note="Di-leucine motif"
SQ SEQUENCE 144 AA; 16518 MW; B8884CAF95FB9ED2 CRC64;
MGPNRIYISV GYSTFGMLVG FSAFIVWNVV YKQPWTAAMG GLSGVLALWA LVTHIMYIQD
YWRTWLKGLK FFMFVSSVFS LLAVAAFATF ITLSVIEKQS LSDPKSFYLS AVWSFMTLKW
AFLLGLYSYR YRQEFADISI LSDF
