HRG1B_XENLA
ID HRG1B_XENLA Reviewed; 145 AA.
AC Q4FZW7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Heme transporter hrg1-B;
DE AltName: Full=Heme-responsive gene 1 protein homolog B;
DE Short=HRG-1B;
DE AltName: Full=Solute carrier family 48 member 1-B;
GN Name=slc48a1-b; Synonyms=hrg1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Heme transporter that regulates intracellular heme
CC availability through the endosomal or lysosomal compartment.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC099008; AAH99008.1; -; mRNA.
DR RefSeq; NP_001090065.1; NM_001096596.2.
DR AlphaFoldDB; Q4FZW7; -.
DR GeneID; 735139; -.
DR KEGG; xla:735139; -.
DR CTD; 735139; -.
DR Xenbase; XB-GENE-6254281; slc48a1.S.
DR OMA; YLSCIWS; -.
DR OrthoDB; 1396314at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 735139; Expressed in egg cell and 19 other tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR Pfam; PF16954; HRG; 2.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..145
FT /note="Heme transporter hrg1-B"
FT /id="PRO_0000348582"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 141..142
FT /note="Di-leucine motif"
SQ SEQUENCE 145 AA; 16651 MW; C41B2EDD650E443D CRC64;
MAVTKQLWIR IIYAAVGTLF GLSAFLVWNV AFVQPWTAAM GGLSGVLALW ALITHIMYVQ
DFWRTWLKGL RFFLCIGVLF FVLALVAFIT FLAVAISEKQ SISDPKSLYL SCVWSFMSMK
WAFLLSLYSY RYRKEFADIS ILSDF