ID   HRG1_CAEEL              Reviewed;         194 AA.
AC   Q21642;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 2.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Heme transporter hrg-1;
DE   AltName: Full=Heme-responsive gene 1 protein;
DE            Short=CeHRG-1;
GN   Name=hrg-1; ORFNames=R02E12.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, HEME-BINDING, TISSUE SPECIFICITY, AND
RP   INDUCTION.
RX   PubMed=18418376; DOI=10.1038/nature06934;
RA   Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA   Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT   "Haem homeostasis is regulated by the conserved and concerted functions of
RT   HRG-1 proteins.";
RL   Nature 453:1127-1131(2008).
CC   -!- FUNCTION: Heme transporter that regulates intracellular heme
CC       availability through the endosomal or lysosomal compartment.
CC       {ECO:0000269|PubMed:18418376}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18418376};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Lysosome
CC       membrane {ECO:0000269|PubMed:18418376}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:18418376}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the intestinal cells in
CC       larvae and adults. {ECO:0000269|PubMed:18418376}.
CC   -!- INDUCTION: By heme deficiency. {ECO:0000269|PubMed:18418376}.
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; FO080560; CCD64658.1; -; Genomic_DNA.
DR   PIR; T16649; T16649.
DR   RefSeq; NP_508690.2; NM_076289.8.
DR   AlphaFoldDB; Q21642; -.
DR   STRING; 6239.R02E12.6.1; -.
DR   TCDB; 2.A.110.1.2; the heme transporter, heme-responsive gene protein (hrg) family.
DR   PaxDb; Q21642; -.
DR   PeptideAtlas; Q21642; -.
DR   EnsemblMetazoa; R02E12.6.1; R02E12.6.1; WBGene00019830.
DR   EnsemblMetazoa; R02E12.6.2; R02E12.6.2; WBGene00019830.
DR   EnsemblMetazoa; R02E12.6.3; R02E12.6.3; WBGene00019830.
DR   UCSC; R02E12.6.3; c. elegans.
DR   WormBase; R02E12.6; CE30099; WBGene00019830; hrg-1.
DR   eggNOG; ENOG502SEBR; Eukaryota.
DR   GeneTree; ENSGT00390000002307; -.
DR   HOGENOM; CLU_1572023_0_0_1; -.
DR   InParanoid; Q21642; -.
DR   OMA; AVWFFMT; -.
DR   OrthoDB; 1396314at2759; -.
DR   PhylomeDB; Q21642; -.
DR   PRO; PR:Q21642; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00019830; Expressed in larva and 3 other tissues.
DR   GO; GO:0010008; C:endosome membrane; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:WormBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IDA:WormBase.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IDA:WormBase.
DR   GO; GO:0015886; P:heme transport; IDA:WormBase.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 1.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   1: Evidence at protein level;
KW   Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..194
FT                   /note="Heme transporter hrg-1"
FT                   /id="PRO_0000348583"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           182..183
FT                   /note="Di-leucine motif"
SQ   SEQUENCE   194 AA;  21737 MW;  86E400C8DCD74C2A CRC64;
     MHQIYSSDVS SITSKSSIAK AEIITMEEEQ QRQSCCTWFH SLKVQIWIAW LGVSAGVMAG
     TVFAIQYQNW IAVTMCFISS GFATLVLHLH LAYKKTQMAG WSETRLRCLA AVGATVSFLS
     FIAMVFCLVV AGIEHQTLDK QGLMGANLWI AAVWFFMTSK WSALTWRFAR KYRAFCEESQ
     PLLAAAPPEY SVTI