HRG1_CHICK
ID HRG1_CHICK Reviewed; 147 AA.
AC Q5ZHU0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Heme transporter HRG1;
DE AltName: Full=Heme-responsive gene 1 protein homolog;
DE Short=HRG-1;
DE AltName: Full=Solute carrier family 48 member 1;
GN Name=SLC48A1; Synonyms=HRG1; ORFNames=RCJMB04_33e14;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Heme transporter that regulates intracellular heme
CC availability through the endosomal or lysosomal compartment.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR EMBL; AJ721044; CAG32703.1; -; mRNA.
DR RefSeq; NP_001026574.1; NM_001031403.2.
DR AlphaFoldDB; Q5ZHU0; -.
DR STRING; 9031.ENSGALP00000029015; -.
DR PaxDb; Q5ZHU0; -.
DR Ensembl; ENSGALT00000074330; ENSGALP00000055141; ENSGALG00000036380.
DR GeneID; 426887; -.
DR KEGG; gga:426887; -.
DR CTD; 55652; -.
DR VEuPathDB; HostDB:geneid_426887; -.
DR eggNOG; ENOG502S0AI; Eukaryota.
DR GeneTree; ENSGT00390000002307; -.
DR InParanoid; Q5ZHU0; -.
DR OMA; YLSCIWS; -.
DR OrthoDB; 1396314at2759; -.
DR PhylomeDB; Q5ZHU0; -.
DR PRO; PR:Q5ZHU0; -.
DR Proteomes; UP000000539; Unplaced.
DR Bgee; ENSGALG00000036380; Expressed in lung and 13 other tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR Pfam; PF16954; HRG; 2.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..147
FT /note="Heme transporter HRG1"
FT /id="PRO_0000348578"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 143..144
FT /note="Di-leucine motif"
SQ SEQUENCE 147 AA; 16523 MW; 96D28C9F4EEED2F0 CRC64;
MAVSRALALR LAYAAAGALM GFSAFFTWSL APAFRQPATA AAGGLSGVLA LWALITHVMY
VQDYWRTWLK GLRFFLFIGI LFSALSVVGF CTFLVLAITQ HQSLTDPRSY YLSCVWSFIS
LKWAFLLSLY AYRYRNEFAD ISILSDF
