HRG1_MOUSE
ID HRG1_MOUSE Reviewed; 146 AA.
AC Q9D8M3; Q3UU69; Q9DCK0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Heme transporter HRG1;
DE AltName: Full=Heme-responsive gene 1 protein homolog;
DE Short=HRG-1;
DE AltName: Full=Solute carrier family 48 member 1;
GN Name=Slc48a1; Synonyms=Hrg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Kidney, Pancreas, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Heme transporter that regulates intracellular heme
CC availability through the endosomal or lysosomal compartment.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR EMBL; AK002729; BAB22311.1; -; mRNA.
DR EMBL; AK007888; BAB25331.1; -; mRNA.
DR EMBL; AK088485; BAC40384.1; -; mRNA.
DR EMBL; AK089421; BAC40874.1; -; mRNA.
DR EMBL; AK138729; BAE23759.1; -; mRNA.
DR EMBL; AK150552; BAE29654.1; -; mRNA.
DR EMBL; AK155824; BAE33448.1; -; mRNA.
DR EMBL; AK159879; BAE35451.1; -; mRNA.
DR EMBL; AK159892; BAE35459.1; -; mRNA.
DR EMBL; AK159898; BAE35464.1; -; mRNA.
DR EMBL; AK170393; BAE41765.1; -; mRNA.
DR EMBL; BC022913; AAH22913.1; -; mRNA.
DR CCDS; CCDS49715.1; -.
DR RefSeq; NP_080629.1; NM_026353.4.
DR AlphaFoldDB; Q9D8M3; -.
DR SMR; Q9D8M3; -.
DR BioGRID; 212409; 1.
DR IntAct; Q9D8M3; 1.
DR STRING; 10090.ENSMUSP00000112644; -.
DR iPTMnet; Q9D8M3; -.
DR PhosphoSitePlus; Q9D8M3; -.
DR jPOST; Q9D8M3; -.
DR MaxQB; Q9D8M3; -.
DR PaxDb; Q9D8M3; -.
DR PeptideAtlas; Q9D8M3; -.
DR PRIDE; Q9D8M3; -.
DR Antibodypedia; 25407; 17 antibodies from 9 providers.
DR DNASU; 67739; -.
DR Ensembl; ENSMUST00000117892; ENSMUSP00000112644; ENSMUSG00000081534.
DR GeneID; 67739; -.
DR KEGG; mmu:67739; -.
DR UCSC; uc007xlb.2; mouse.
DR CTD; 55652; -.
DR MGI; MGI:1914989; Slc48a1.
DR VEuPathDB; HostDB:ENSMUSG00000081534; -.
DR eggNOG; ENOG502S0AI; Eukaryota.
DR GeneTree; ENSGT00390000002307; -.
DR HOGENOM; CLU_148774_0_0_1; -.
DR InParanoid; Q9D8M3; -.
DR OMA; YLSCIWS; -.
DR OrthoDB; 1396314at2759; -.
DR PhylomeDB; Q9D8M3; -.
DR TreeFam; TF332621; -.
DR BioGRID-ORCS; 67739; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Slc48a1; mouse.
DR PRO; PR:Q9D8M3; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9D8M3; protein.
DR Bgee; ENSMUSG00000081534; Expressed in blood and 243 other tissues.
DR ExpressionAtlas; Q9D8M3; baseline and differential.
DR Genevisible; Q9D8M3; MM.
DR GO; GO:0010008; C:endosome membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0020037; F:heme binding; ISO:MGI.
DR GO; GO:0015232; F:heme transmembrane transporter activity; ISO:MGI.
DR GO; GO:0015886; P:heme transport; ISO:MGI.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR Pfam; PF16954; HRG; 2.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..146
FT /note="Heme transporter HRG1"
FT /id="PRO_0000348576"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 142..143
FT /note="Di-leucine motif"
FT CONFLICT 98
FT /note="T -> N (in Ref. 1; BAB22311)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="Y -> C (in Ref. 1; BAE23759)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 146 AA; 16489 MW; D71B3DBB4AC38A3B CRC64;
MAPSRLQLGL RAAYSGFSSV AGFSIFFVWT VVYRQPGTAA MGGLAGVLAL WVLVTHVMYM
QDYWRTWLRG LRGFFFVGAL FSAVSVSAFC TFLALAITQH QSLKDPNSYY LSCVWSFISF
KWAFLLSLYA HRYRADFADI SILSDF
