ID   HRG1_RAT                Reviewed;         146 AA.
AC   B0BNL4; Q3KR77;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Heme transporter HRG1;
DE   AltName: Full=Heme-responsive gene 1 protein homolog;
DE            Short=HRG-1;
DE   AltName: Full=Solute carrier family 48 member 1;
GN   Name=Slc48a1; Synonyms=Hrg1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Prostate, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Heme transporter that regulates intracellular heme
CC       availability through the endosomal or lysosomal compartment.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B0BNL4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B0BNL4-2; Sequence=VSP_035185;
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; CH474035; EDL87099.1; -; Genomic_DNA.
DR   EMBL; BC105856; AAI05857.1; -; mRNA.
DR   EMBL; BC158869; AAI58870.1; -; mRNA.
DR   RefSeq; NP_001120928.1; NM_001127456.1. [B0BNL4-1]
DR   AlphaFoldDB; B0BNL4; -.
DR   STRING; 10116.ENSRNOP00000010957; -.
DR   PaxDb; B0BNL4; -.
DR   Ensembl; ENSRNOT00000105518; ENSRNOP00000077408; ENSRNOG00000053196. [B0BNL4-2]
DR   Ensembl; ENSRNOT00000110329; ENSRNOP00000093159; ENSRNOG00000053196. [B0BNL4-1]
DR   GeneID; 300191; -.
DR   KEGG; rno:300191; -.
DR   UCSC; RGD:1562880; rat. [B0BNL4-1]
DR   CTD; 55652; -.
DR   RGD; 1562880; Slc48a1.
DR   eggNOG; ENOG502S0AI; Eukaryota.
DR   GeneTree; ENSGT00390000002307; -.
DR   HOGENOM; CLU_148774_0_0_1; -.
DR   InParanoid; B0BNL4; -.
DR   OMA; YLSCIWS; -.
DR   OrthoDB; 1396314at2759; -.
DR   PRO; PR:B0BNL4; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Proteomes; UP000234681; Chromosome 7.
DR   Bgee; ENSRNOG00000053196; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; B0BNL4; RN.
DR   GO; GO:0010008; C:endosome membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0020037; F:heme binding; ISO:RGD.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0015886; P:heme transport; ISO:RGD.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 2.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Endosome; Lysosome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..146
FT                   /note="Heme transporter HRG1"
FT                   /id="PRO_0000348577"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           142..143
FT                   /note="Di-leucine motif"
FT   VAR_SEQ         1..57
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_035185"
SQ   SEQUENCE   146 AA;  16615 MW;  52D31141782148F8 CRC64;
     MAPTRLQLGV RAAYSGFSSL AGFSIFFVWT VVYRQPGTAA MGGLAGVLAL WVLVTHVMYM
     QDYWRTWLRG LRGFFFVGAL FSAVSFSAFC TFLTLAITQH QSFKDPNSYY LSCVWSFISF
     KWAFLLSLYA HRYRADFADI SILSDF