HRG4_CAEEL
ID HRG4_CAEEL Reviewed; 184 AA.
AC Q20106; A0A061AD77; B3GWC4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Heme transporter hrg-4;
DE AltName: Full=Heme-responsive gene 4 protein;
DE Short=CeHRG-4;
GN Name=hrg-4 {ECO:0000312|WormBase:F36H1.5c};
GN ORFNames=F36H1.5 {ECO:0000312|WormBase:F36H1.5c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, HEME-BINDING, AND INDUCTION.
RX PubMed=18418376; DOI=10.1038/nature06934;
RA Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT "Haem homeostasis is regulated by the conserved and concerted functions of
RT HRG-1 proteins.";
RL Nature 453:1127-1131(2008).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28581477; DOI=10.1038/ncb3539;
RA Sinclair J., Pinter K., Samuel T., Beardsley S., Yuan X., Zhang J.,
RA Meng K., Yun S., Krause M., Hamza I.;
RT "Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.";
RL Nat. Cell Biol. 19:799-807(2017).
CC -!- FUNCTION: Heme transporter that mediates heme uptake across the plasma
CC membrane. {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:28581477}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=c {ECO:0000312|WormBase:F36H1.5c};
CC IsoId=Q20106-3; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F36H1.5b};
CC IsoId=Q20106-2; Sequence=VSP_058209;
CC -!- INDUCTION: By heme deficiency. {ECO:0000269|PubMed:18418376}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in the heme
CC accumulation in the intestine under low heme conditions
CC (PubMed:28581477). Simultaneous RNAi-mediated knockdown with hrg-7
CC results in defective heme deficiency sensing (PubMed:28581477).
CC {ECO:0000269|PubMed:28581477}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR EMBL; BX284604; CAQ58110.1; -; Genomic_DNA.
DR EMBL; BX284604; CDR32813.1; -; Genomic_DNA.
DR PIR; T21881; T21881.
DR RefSeq; NP_001129857.1; NM_001136385.1. [Q20106-2]
DR RefSeq; NP_001294019.1; NM_001307090.1. [Q20106-3]
DR AlphaFoldDB; Q20106; -.
DR STRING; 6239.F36H1.5a; -.
DR TCDB; 2.A.110.1.3; the heme transporter, heme-responsive gene protein (hrg) family.
DR EPD; Q20106; -.
DR PRIDE; Q20106; -.
DR EnsemblMetazoa; F36H1.5b.1; F36H1.5b.1; WBGene00009493. [Q20106-2]
DR EnsemblMetazoa; F36H1.5c.1; F36H1.5c.1; WBGene00009493. [Q20106-3]
DR GeneID; 185380; -.
DR KEGG; cel:CELE_F36H1.5; -.
DR UCSC; F36H1.5; c. elegans. [Q20106-3]
DR CTD; 185380; -.
DR WormBase; F36H1.5b; CE42667; WBGene00009493; hrg-4. [Q20106-2]
DR WormBase; F36H1.5c; CE49968; WBGene00009493; hrg-4. [Q20106-3]
DR eggNOG; ENOG502TKK0; Eukaryota.
DR GeneTree; ENSGT00390000002307; -.
DR HOGENOM; CLU_094341_0_0_1; -.
DR InParanoid; Q20106; -.
DR OMA; LMIWPNI; -.
DR OrthoDB; 1440035at2759; -.
DR PRO; PR:Q20106; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00009493; Expressed in larva and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR GO; GO:0020037; F:heme binding; IDA:WormBase.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IDA:WormBase.
DR GO; GO:0015886; P:heme transport; IDA:WormBase.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR Pfam; PF16954; HRG; 1.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..184
FT /note="Heme transporter hrg-4"
FT /id="PRO_0000348584"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 116..130
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058209"
SQ SEQUENCE 184 AA; 20745 MW; 3A6A4BEA67208636 CRC64;
MTAENRGFCQ LICHINVRIG WTIFGIVFGI SAILTYAIKF HNWSATATTA IATLFACETL
YLYWALKKNT IVNWKSSTFQ LMIWPNVFIG LLGLLGCLVC YIIAGITHQG AGSIQGWSLF
KCSIYFSKFA AMYGENLWFT GSWSLVITKW TWQNAFFARK YLNKIGTASE DGDIDDDDVE
VIKS
