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HRG4_CAEEL
ID   HRG4_CAEEL              Reviewed;         184 AA.
AC   Q20106; A0A061AD77; B3GWC4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Heme transporter hrg-4;
DE   AltName: Full=Heme-responsive gene 4 protein;
DE            Short=CeHRG-4;
GN   Name=hrg-4 {ECO:0000312|WormBase:F36H1.5c};
GN   ORFNames=F36H1.5 {ECO:0000312|WormBase:F36H1.5c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, HEME-BINDING, AND INDUCTION.
RX   PubMed=18418376; DOI=10.1038/nature06934;
RA   Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA   Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT   "Haem homeostasis is regulated by the conserved and concerted functions of
RT   HRG-1 proteins.";
RL   Nature 453:1127-1131(2008).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28581477; DOI=10.1038/ncb3539;
RA   Sinclair J., Pinter K., Samuel T., Beardsley S., Yuan X., Zhang J.,
RA   Meng K., Yun S., Krause M., Hamza I.;
RT   "Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.";
RL   Nat. Cell Biol. 19:799-807(2017).
CC   -!- FUNCTION: Heme transporter that mediates heme uptake across the plasma
CC       membrane. {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:28581477}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=c {ECO:0000312|WormBase:F36H1.5c};
CC         IsoId=Q20106-3; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:F36H1.5b};
CC         IsoId=Q20106-2; Sequence=VSP_058209;
CC   -!- INDUCTION: By heme deficiency. {ECO:0000269|PubMed:18418376}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in the heme
CC       accumulation in the intestine under low heme conditions
CC       (PubMed:28581477). Simultaneous RNAi-mediated knockdown with hrg-7
CC       results in defective heme deficiency sensing (PubMed:28581477).
CC       {ECO:0000269|PubMed:28581477}.
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; BX284604; CAQ58110.1; -; Genomic_DNA.
DR   EMBL; BX284604; CDR32813.1; -; Genomic_DNA.
DR   PIR; T21881; T21881.
DR   RefSeq; NP_001129857.1; NM_001136385.1. [Q20106-2]
DR   RefSeq; NP_001294019.1; NM_001307090.1. [Q20106-3]
DR   AlphaFoldDB; Q20106; -.
DR   STRING; 6239.F36H1.5a; -.
DR   TCDB; 2.A.110.1.3; the heme transporter, heme-responsive gene protein (hrg) family.
DR   EPD; Q20106; -.
DR   PRIDE; Q20106; -.
DR   EnsemblMetazoa; F36H1.5b.1; F36H1.5b.1; WBGene00009493. [Q20106-2]
DR   EnsemblMetazoa; F36H1.5c.1; F36H1.5c.1; WBGene00009493. [Q20106-3]
DR   GeneID; 185380; -.
DR   KEGG; cel:CELE_F36H1.5; -.
DR   UCSC; F36H1.5; c. elegans. [Q20106-3]
DR   CTD; 185380; -.
DR   WormBase; F36H1.5b; CE42667; WBGene00009493; hrg-4. [Q20106-2]
DR   WormBase; F36H1.5c; CE49968; WBGene00009493; hrg-4. [Q20106-3]
DR   eggNOG; ENOG502TKK0; Eukaryota.
DR   GeneTree; ENSGT00390000002307; -.
DR   HOGENOM; CLU_094341_0_0_1; -.
DR   InParanoid; Q20106; -.
DR   OMA; LMIWPNI; -.
DR   OrthoDB; 1440035at2759; -.
DR   PRO; PR:Q20106; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00009493; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:WormBase.
DR   GO; GO:0020037; F:heme binding; IDA:WormBase.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IDA:WormBase.
DR   GO; GO:0015886; P:heme transport; IDA:WormBase.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 1.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..184
FT                   /note="Heme transporter hrg-4"
FT                   /id="PRO_0000348584"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         116..130
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_058209"
SQ   SEQUENCE   184 AA;  20745 MW;  3A6A4BEA67208636 CRC64;
     MTAENRGFCQ LICHINVRIG WTIFGIVFGI SAILTYAIKF HNWSATATTA IATLFACETL
     YLYWALKKNT IVNWKSSTFQ LMIWPNVFIG LLGLLGCLVC YIIAGITHQG AGSIQGWSLF
     KCSIYFSKFA AMYGENLWFT GSWSLVITKW TWQNAFFARK YLNKIGTASE DGDIDDDDVE
     VIKS
 
 
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