HRG5_CAEEL
ID HRG5_CAEEL Reviewed; 160 AA.
AC Q7YTM8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Heme transporter hrg-5;
DE AltName: Full=Heme-responsive gene 5 protein;
DE Short=CeHRG-5;
GN Name=hrg-5; ORFNames=F36H1.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP INDUCTION.
RX PubMed=18418376; DOI=10.1038/nature06934;
RA Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT "Haem homeostasis is regulated by the conserved and concerted functions of
RT HRG-1 proteins.";
RL Nature 453:1127-1131(2008).
CC -!- FUNCTION: Heme transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Constitutively expressed. Not regulated by heme level.
CC {ECO:0000269|PubMed:18418376}.
CC -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR EMBL; Z68760; CAE17822.1; -; Genomic_DNA.
DR RefSeq; NP_001023184.1; NM_001028013.1.
DR AlphaFoldDB; Q7YTM8; -.
DR SMR; Q7YTM8; -.
DR STRING; 6239.F36H1.9; -.
DR PaxDb; Q7YTM8; -.
DR EnsemblMetazoa; F36H1.9.1; F36H1.9.1; WBGene00009494.
DR EnsemblMetazoa; F36H1.9.2; F36H1.9.2; WBGene00009494.
DR GeneID; 3565185; -.
DR KEGG; cel:CELE_F36H1.9; -.
DR UCSC; F36H1.9; c. elegans.
DR CTD; 3565185; -.
DR WormBase; F36H1.9; CE34853; WBGene00009494; hrg-5.
DR eggNOG; ENOG502TJR3; Eukaryota.
DR GeneTree; ENSGT00390000002307; -.
DR HOGENOM; CLU_094341_0_0_1; -.
DR InParanoid; Q7YTM8; -.
DR OMA; VACHTLQ; -.
DR OrthoDB; 1771096at2759; -.
DR PhylomeDB; Q7YTM8; -.
DR PRO; PR:Q7YTM8; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00009494; Expressed in larva and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR InterPro; IPR026218; HRG.
DR PANTHER; PTHR31525; PTHR31525; 1.
DR PRINTS; PR02095; TRNSPORTRHRG.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..160
FT /note="Heme transporter hrg-5"
FT /id="PRO_0000348585"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 18322 MW; F456240854EA259D CRC64;
MSSKISSSRC CTLFCHVNTR IALTILDILI GFSNILSYAI QFHNWSALTL TAMVTLVACH
TLQMFLAEKK NTITHWKYST FKWIMWIDIT LGFLALGCFV VCFIIAGVTE IEFTNLYGEN
LWFTGLWATA ITKYTWQNAL LARNYSNQKR ILKSEIVEDA
