ID   HRG6_CAEEL              Reviewed;         161 AA.
AC   Q7YTM7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Heme transporter hrg-6;
DE   AltName: Full=Heme-responsive gene 6 protein;
DE            Short=CeHRG-6;
GN   Name=hrg-6; ORFNames=F36H1.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=18418376; DOI=10.1038/nature06934;
RA   Rajagopal A., Rao A.U., Amigo J., Tian M., Upadhyay S.K., Hall C., Uhm S.,
RA   Mathew M.K., Fleming M.D., Paw B.H., Krause M., Hamza I.;
RT   "Haem homeostasis is regulated by the conserved and concerted functions of
RT   HRG-1 proteins.";
RL   Nature 453:1127-1131(2008).
CC   -!- FUNCTION: Heme transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Constitutively expressed. Not regulated by heme level.
CC       {ECO:0000269|PubMed:18418376}.
CC   -!- SIMILARITY: Belongs to the HRG family. {ECO:0000305}.
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DR   EMBL; Z68760; CAE17823.1; -; Genomic_DNA.
DR   RefSeq; NP_001255528.1; NM_001268599.1.
DR   AlphaFoldDB; Q7YTM7; -.
DR   STRING; 6239.F36H1.10a; -.
DR   TCDB; 2.A.110.1.5; the heme transporter, heme-responsive gene protein (hrg) family.
DR   PaxDb; Q7YTM7; -.
DR   EnsemblMetazoa; F36H1.10a.1; F36H1.10a.1; WBGene00009495.
DR   GeneID; 3565935; -.
DR   KEGG; cel:CELE_F36H1.10; -.
DR   UCSC; F36H1.10; c. elegans.
DR   CTD; 3565935; -.
DR   WormBase; F36H1.10a; CE34850; WBGene00009495; hrg-6.
DR   eggNOG; ENOG502TGTQ; Eukaryota.
DR   GeneTree; ENSGT00390000002307; -.
DR   HOGENOM; CLU_094341_0_0_1; -.
DR   InParanoid; Q7YTM7; -.
DR   OMA; GVSNKDQ; -.
DR   OrthoDB; 1421552at2759; -.
DR   PhylomeDB; Q7YTM7; -.
DR   PRO; PR:Q7YTM7; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00009495; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; Q7YTM7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015886; P:heme transport; IBA:GO_Central.
DR   InterPro; IPR026218; HRG.
DR   PANTHER; PTHR31525; PTHR31525; 1.
DR   Pfam; PF16954; HRG; 2.
DR   PRINTS; PR02095; TRNSPORTRHRG.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..161
FT                   /note="Heme transporter hrg-6"
FT                   /id="PRO_0000348586"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   161 AA;  18746 MW;  5DFC1198ECAB3873 CRC64;
     MRWSLCCHIN VRIAYTICGI IIGLFWACVY IFAWKNWVAL AACLTATAFA FETFYFYLSV
     KRDTILNWKS QTFQVLFWIN LIVGFLSIGG MITAIVLAAT KHQGVSNKDQ HGLNWWSTAT
     WFLVMLKWTW QNAFIARYYG KLLTKSIIHP EEPDDPSTWK F