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HRH1_BOVIN
ID   HRH1_BOVIN              Reviewed;         491 AA.
AC   P30546;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Histamine H1 receptor;
DE            Short=H1R;
DE            Short=HH1R;
GN   Name=HRH1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Adrenal medulla;
RX   PubMed=1722337; DOI=10.1073/pnas.88.24.11515;
RA   Yamashita M., Fukui H., Sugama K., Horio Y., Ito S., Mizuguchi H., Wada H.;
RT   "Expression cloning of a cDNA encoding the bovine histamine H1 receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:11515-11519(1991).
CC   -!- FUNCTION: In peripheral tissues, the H1 subclass of histamine receptors
CC       mediates the contraction of smooth muscles, increase in capillary
CC       permeability due to contraction of terminal venules, and catecholamine
CC       release from adrenal medulla, as well as mediating neurotransmission in
CC       the central nervous system. {ECO:0000269|PubMed:1722337}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1722337};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:1722337}.
CC   -!- TISSUE SPECIFICITY: Brain, lung, small intestine, uterus, adrenal
CC       medulla and spleen. {ECO:0000269|PubMed:1722337}.
CC   -!- PTM: Phosphorylation at sites in the second and third cytoplasmic loops
CC       independently contribute to agonist-induced receptor down-regulation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D10197; BAA01045.1; -; mRNA.
DR   PIR; A41632; A41632.
DR   AlphaFoldDB; P30546; -.
DR   SMR; P30546; -.
DR   STRING; 9913.ENSBTAP00000001896; -.
DR   BindingDB; P30546; -.
DR   ChEMBL; CHEMBL3573; -.
DR   PaxDb; P30546; -.
DR   PRIDE; P30546; -.
DR   eggNOG; KOG4220; Eukaryota.
DR   InParanoid; P30546; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR   GO; GO:0004969; F:histamine receptor activity; IMP:UniProtKB.
DR   GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR   GO; GO:0071420; P:cellular response to histamine; IMP:UniProtKB.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:UniProtKB.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0043114; P:regulation of vascular permeability; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000921; Histamine_H1_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00530; HISTAMINEH1R.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..491
FT                   /note="Histamine H1 receptor"
FT                   /id="PRO_0000069673"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        31..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        54..63
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        85..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        103..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        125..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        145..165
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        166..190
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        191..211
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        212..420
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        421..442
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        443..454
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        455..474
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        475..491
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          108..113
FT                   /note="Important for agonist binding"
FT                   /evidence="ECO:0000250"
FT   REGION          246..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..432
FT                   /note="Important for agonist binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        255..269
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         141
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         143
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         231
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         384
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70174"
FT   MOD_RES         400
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         402
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   DISULFID        445..448
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   491 AA;  55957 MW;  DAA349E52218CE28 CRC64;
     MTCPNSSCVF EDKMCQGNKT APANDAQLTP LVVVLSTISL VTVGLNLLVL YAVRSERKLH
     TVGNLYIVSL SVADLIVGVV VMPMNILYLL MSRWSLGRPL CLFWLSMDYV ASTASIFSVF
     ILCIDRYRSV QQPLKYLRYR TKTRASITIL AAWFLSFLWI IPILGWRHFQ PKTPEPREDK
     CETDFYNVTW FKVMTAIINF YLPTLLMLWF YAKIYKAVRQ HCQHRELING SFPSFSDMKM
     KPENLQVGAK KPGKESPWEV LKRKPKDTGG GPVLKPPSQE PKEVTSPGVF SQEKEEKDGE
     LGKFYCFPLD TVQAQPEAEG SGRGYATINQ SQNQLEMGEQ GLSMPGAKEA LEDQILGDSQ
     SFSRTDSDTP AEPAPAKGKS RSESSTGLEY IKFTWKRLRS HSRQYVSGLH MNRERKAAKQ
     LGFIMAAFII CWIPYFIFFM VIAFCESCCN QHVHMFTIWL GYINSTLNPL IYPLCNENFK
     KTFKKILHIR S
 
 
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