位置:首页 > 蛋白库 > HRH1_RAT
HRH1_RAT
ID   HRH1_RAT                Reviewed;         486 AA.
AC   P31390;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 144.
DE   RecName: Full=Histamine H1 receptor;
DE            Short=H1R;
DE            Short=HH1R;
GN   Name=Hrh1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=7678492; DOI=10.1006/bbrc.1993.1045;
RA   Fujimoto K., Horio Y., Sugama K., Ito S., Liu Y.Q., Fukui H.;
RT   "Genomic cloning of the rat histamine H1 receptor.";
RL   Biochem. Biophys. Res. Commun. 190:294-301(1993).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: In peripheral tissues, the H1 subclass of histamine receptors
CC       mediates the contraction of smooth muscles, increase in capillary
CC       permeability due to contraction of terminal venules, and catecholamine
CC       release from adrenal medulla, as well as mediating neurotransmission in
CC       the central nervous system. {ECO:0000269|PubMed:7678492}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7678492};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:7678492}.
CC   -!- PTM: Phosphorylation at sites in the second and third cytoplasmic loops
CC       independently contribute to agonist-induced receptor down-regulation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D12800; BAA02245.1; -; Genomic_DNA.
DR   PIR; JC1415; JC1415.
DR   RefSeq; NP_058714.1; NM_017018.1.
DR   AlphaFoldDB; P31390; -.
DR   SMR; P31390; -.
DR   STRING; 10116.ENSRNOP00000009775; -.
DR   BindingDB; P31390; -.
DR   ChEMBL; CHEMBL4701; -.
DR   DrugCentral; P31390; -.
DR   GlyGen; P31390; 2 sites.
DR   PhosphoSitePlus; P31390; -.
DR   PaxDb; P31390; -.
DR   GeneID; 24448; -.
DR   KEGG; rno:24448; -.
DR   UCSC; RGD:2830; rat.
DR   CTD; 3269; -.
DR   RGD; 2830; Hrh1.
DR   eggNOG; KOG4220; Eukaryota.
DR   InParanoid; P31390; -.
DR   OrthoDB; 1245472at2759; -.
DR   PhylomeDB; P31390; -.
DR   Reactome; R-RNO-390650; Histamine receptors.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   PRO; PR:P31390; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR   GO; GO:0051381; F:histamine binding; IMP:RGD.
DR   GO; GO:0004969; F:histamine receptor activity; ISS:UniProtKB.
DR   GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR   GO; GO:0071420; P:cellular response to histamine; ISS:UniProtKB.
DR   GO; GO:0007268; P:chemical synaptic transmission; IDA:RGD.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007199; P:G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; TAS:RGD.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR   GO; GO:0007613; P:memory; ISO:RGD.
DR   GO; GO:0010894; P:negative regulation of steroid biosynthetic process; IMP:RGD.
DR   GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IDA:RGD.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; ISO:RGD.
DR   GO; GO:0043114; P:regulation of vascular permeability; IEA:InterPro.
DR   GO; GO:0009629; P:response to gravity; IEP:RGD.
DR   GO; GO:0008542; P:visual learning; ISO:RGD.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000921; Histamine_H1_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00530; HISTAMINEH1R.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..486
FT                   /note="Histamine H1 receptor"
FT                   /id="PRO_0000069680"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        30..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        53..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        84..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        102..123
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        124..143
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        144..164
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        165..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        211..415
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        416..437
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        438..449
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        450..469
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        470..486
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          107..112
FT                   /note="Important for agonist binding"
FT                   /evidence="ECO:0000250"
FT   REGION          241..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..427
FT                   /note="Important for agonist binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        241..260
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         140
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         142
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         230
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         342
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70174"
FT   MOD_RES         345
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70174"
FT   MOD_RES         379
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70174"
FT   MOD_RES         381
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70174"
FT   MOD_RES         395
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   MOD_RES         397
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35367"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        100..180
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   DISULFID        440..443
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   486 AA;  55693 MW;  E44C02A743A95E88 CRC64;
     MSFANTSSTF EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY AVHSERKLHT
     VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC LFWLSMDYVA STASIFSVFI
     LCIDRYRSVQ QPLRYLRYRT KTRASATILG AWFFSFLWVI PILGWHHFMP PAPELREDKC
     ETDFYNVTWF KIMTAIINFY LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPSFSELKLR
     SDDTKEGAKK PGRESPWGVL KRPSRDPSVG LDQKSTSEDP KMTSPTVFSQ EGERETRPCF
     RLDIMQKQSV AEGDVRGSKA NDQALSQPKM DEQSLNTCRR ISETSEDQTL VDQQSFSRTT
     DSDTSIEPGP GRVKSRSGSN SGLDYIKITW KRLRSHSRQY VSGLHLNRER KAAKQLGFIM
     AAFILCWIPY FIFFMVIAFC KSCCSEPMHM FTIWLGYINS TLNPLIYPLC NENFKKTFKK
     ILHIRS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024