HRH2_MOUSE
ID HRH2_MOUSE Reviewed; 397 AA.
AC P97292; Q9D282;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Histamine H2 receptor;
DE Short=H2R;
DE Short=HH2R;
DE AltName: Full=Gastric receptor I;
GN Name=Hrh2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Corpus striatum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-358.
RC STRAIN=129/Ola;
RX PubMed=8938453; DOI=10.1006/geno.1996.0575;
RA Kobayashi T., Inoue I., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Watanabe T.;
RT "Cloning, RNA expression, and chromosomal location of a mouse histamine H2
RT receptor gene.";
RL Genomics 37:390-394(1996).
CC -!- FUNCTION: The H2 subclass of histamine receptors mediates gastric acid
CC secretion. The activity of this receptor is mediated by G proteins
CC which activate adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK020259; BAB32044.1; -; mRNA.
DR EMBL; AK163760; BAE37484.1; -; mRNA.
DR EMBL; AC163343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC164086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; D50096; BAA08792.1; -; Genomic_DNA.
DR CCDS; CCDS26526.1; -.
DR RefSeq; NP_001010973.1; NM_001010973.2.
DR RefSeq; NP_032312.2; NM_008286.2.
DR RefSeq; XP_006516915.1; XM_006516852.2.
DR RefSeq; XP_017170886.1; XM_017315397.1.
DR AlphaFoldDB; P97292; -.
DR SMR; P97292; -.
DR STRING; 10090.ENSMUSP00000038170; -.
DR BindingDB; P97292; -.
DR ChEMBL; CHEMBL2245; -.
DR GlyGen; P97292; 1 site.
DR iPTMnet; P97292; -.
DR PhosphoSitePlus; P97292; -.
DR PaxDb; P97292; -.
DR PRIDE; P97292; -.
DR Antibodypedia; 2931; 343 antibodies from 39 providers.
DR DNASU; 15466; -.
DR Ensembl; ENSMUST00000038101; ENSMUSP00000038170; ENSMUSG00000034987.
DR GeneID; 15466; -.
DR KEGG; mmu:15466; -.
DR UCSC; uc007qob.1; mouse.
DR CTD; 3274; -.
DR MGI; MGI:108482; Hrh2.
DR VEuPathDB; HostDB:ENSMUSG00000034987; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000158761; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; P97292; -.
DR OMA; ITYYRIL; -.
DR OrthoDB; 929700at2759; -.
DR PhylomeDB; P97292; -.
DR TreeFam; TF316350; -.
DR Reactome; R-MMU-390650; Histamine receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 15466; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Dhx15; mouse.
DR PRO; PR:P97292; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P97292; protein.
DR Bgee; ENSMUSG00000034987; Expressed in granulocyte and 40 other tissues.
DR ExpressionAtlas; P97292; baseline and differential.
DR Genevisible; P97292; MM.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:1901363; F:heterocyclic compound binding; ISO:MGI.
DR GO; GO:0004969; F:histamine receptor activity; ISO:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0048565; P:digestive tract development; IMP:MGI.
DR GO; GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0001696; P:gastric acid secretion; IGI:MGI.
DR GO; GO:0001698; P:gastrin-induced gastric acid secretion; IMP:MGI.
DR GO; GO:0048732; P:gland development; IMP:MGI.
DR GO; GO:0001697; P:histamine-induced gastric acid secretion; IMP:MGI.
DR GO; GO:0007613; P:memory; IMP:MGI.
DR GO; GO:1900139; P:negative regulation of arachidonic acid secretion; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
DR GO; GO:1901998; P:toxin transport; IMP:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000503; Histamine_H2_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00531; HISTAMINEH2R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..397
FT /note="Histamine H2 receptor"
FT /id="PRO_0000069685"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..397
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT SITE 98
FT /note="Essential for histamine binding"
FT /evidence="ECO:0000250"
FT SITE 185
FT /note="Essential for tiotidine binding and implicated in
FT histamine binding"
FT /evidence="ECO:0000250"
FT SITE 189
FT /note="Implicated in histamine binding"
FT /evidence="ECO:0000250"
FT LIPID 304
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 91..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 85
FT /note="S -> R (in Ref. 3; BAA08792)"
FT /evidence="ECO:0000305"
FT CONFLICT 263
FT /note="A -> P (in Ref. 3; BAA08792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 397 AA; 44794 MW; BB4719084F4BDD59 CRC64;
MEPNGTVHSC CLDSIALKVT ISVVLTTLIF ITVAGNVVVC LAVSLNRRLR SLTNCFIVSL
AATDLLLGLL VMPFSAIYQL SFKWSFGQVF CNIYTSLDVM LCTASILNLF MISLDRYCAV
TDPLRYPVLV TPVRVAISLV FIWVISITLS FLSIHLGWNS RNGTRGGNDT FKCKVQVNEV
YGLVDGMVTF YLPLLIMCVT YYRIFKIARE QAKRINHISS WKAATIREHK ATVTLAAVMG
AFIVCWFPYF TAFVYRGLRG DDAVNEVVEG IVLWLGYANS ALNPILYATL NRDFRMAYQQ
LFHCKLASHN SHKTSLRLNN SLLSRSQSRE GRWQEEKPLK LQVWSGTELT HPQGSPVRTR
LSHSSCLLSL SLLSFIWKLG TWIHHRRPFQ PSLHISA
