HRH3_CAVPO
ID HRH3_CAVPO Reviewed; 445 AA.
AC Q9JI35; Q9JI36;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Histamine H3 receptor;
DE Short=H3R;
DE Short=HH3R;
GN Name=HRH3;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RC TISSUE=Brain;
RX PubMed=10757514; DOI=10.1097/00001756-200003200-00020;
RA Tardivel-Lacombe J., Rouleau A., Heron A., Morisset S., Pillot C.,
RA Cochois V., Schwartz J.-C., Arrang J.-M.;
RT "Cloning and cerebral expression of the guinea pig histamine H3 receptor:
RT evidence for two isoforms.";
RL NeuroReport 11:755-759(2000).
CC -!- FUNCTION: The H3 subclass of histamine receptors could mediate the
CC histamine signals in CNS and peripheral nervous system. Signals through
CC the inhibition of adenylate cyclase and displays high constitutive
CC activity (spontaneous activity in the absence of agonist).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long; Synonyms=H3L;
CC IsoId=Q9JI35-1; Sequence=Displayed;
CC Name=Short; Synonyms=H3S;
CC IsoId=Q9JI35-2; Sequence=VSP_001880;
CC -!- TISSUE SPECIFICITY: Expressed widely and abundantly throughout the
CC brain. Highly expressed in discrete neuronal populations such as
CC pyramidal cells in cerebral cortex or cerebellar Purkinje cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF267537; AAF78947.1; -; mRNA.
DR EMBL; AF267538; AAF78950.1; -; mRNA.
DR RefSeq; NP_001166208.1; NM_001172737.1. [Q9JI35-1]
DR AlphaFoldDB; Q9JI35; -.
DR SMR; Q9JI35; -.
DR STRING; 10141.ENSCPOP00000020710; -.
DR BindingDB; Q9JI35; -.
DR ChEMBL; CHEMBL5076; -.
DR DrugCentral; Q9JI35; -.
DR GeneID; 100135541; -.
DR KEGG; cpoc:100135541; -.
DR CTD; 11255; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9JI35; -.
DR OrthoDB; 614573at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004969; F:histamine receptor activity; IEA:InterPro.
DR GO; GO:0001505; P:regulation of neurotransmitter levels; IEA:InterPro.
DR CDD; cd15296; 7tmA_Histamine_H3R; 1.
DR InterPro; IPR041998; 7tmA_HRH3.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003980; Histamine_H3_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01471; HISTAMINEH3R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..445
FT /note="Histamine H3 receptor"
FT /id="PRO_0000069689"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..445
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 236..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 439
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P58406"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 276..305
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:10757514"
FT /id="VSP_001880"
SQ SEQUENCE 445 AA; 48735 MW; BAE206A3887189A0 CRC64;
MERAPPDGLM NASGALAGEA AAAAGGARTF SAAWTAVLAA LMALLIVATV LGNALVMLAF
VADSSLRTQN NFFLLNLAIS DFLVGVFCIP LYVPYVLTGR WTFGRGLCKL WLVVDYLLCT
SSVFNIVLIS YDRFLSVTRA VSYRAQQGDT RRAVRKMVLV WVLAFLLYGP AILSWEYLSG
GSSIPEGHCY AEFFYNWYFL ITASTLEFFT PFLSVTFFNL SIYLNIQRRT RLRLDGGARE
AGPDPLPEAQ SSPPQPPPGC WGCWPKGQGE SMPLHRYGVG EAGPGAEAGE AALGGGSGAA
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL SRDKKVAKSL
AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHYSFR
RAFTKLLCPQ KLKVQPHSSL EHCWK
