HRH3_MOUSE
ID HRH3_MOUSE Reviewed; 445 AA.
AC P58406;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Histamine H3 receptor;
DE Short=H3R;
DE Short=HH3R;
GN Name=Hrh3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RA Coge F., Rique H., Levacher B., Leopold O., Guenin S.-P., Boutin J.A.,
RA Galizzi J.-P.;
RT "Cloning of mouse histamine H3 receptor.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: The H3 subclass of histamine receptors could mediate the
CC histamine signals in CNS and peripheral nervous system. Signals through
CC the inhibition of adenylate cyclase and displays high constitutive
CC activity (spontaneous activity in the absence of agonist) (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY044153; AAK72406.1; -; mRNA.
DR CCDS; CCDS17169.1; -.
DR RefSeq; NP_598610.1; NM_133849.3.
DR AlphaFoldDB; P58406; -.
DR SMR; P58406; -.
DR STRING; 10090.ENSMUSP00000049963; -.
DR BindingDB; P58406; -.
DR ChEMBL; CHEMBL3263; -.
DR DrugCentral; P58406; -.
DR GuidetoPHARMACOLOGY; 264; -.
DR GlyGen; P58406; 1 site.
DR iPTMnet; P58406; -.
DR PhosphoSitePlus; P58406; -.
DR SwissPalm; P58406; -.
DR PaxDb; P58406; -.
DR PRIDE; P58406; -.
DR ProteomicsDB; 267018; -.
DR Antibodypedia; 14714; 499 antibodies from 36 providers.
DR DNASU; 99296; -.
DR Ensembl; ENSMUST00000056480; ENSMUSP00000049963; ENSMUSG00000039059.
DR GeneID; 99296; -.
DR KEGG; mmu:99296; -.
DR UCSC; uc008oij.2; mouse.
DR CTD; 11255; -.
DR MGI; MGI:2139279; Hrh3.
DR VEuPathDB; HostDB:ENSMUSG00000039059; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161502; -.
DR InParanoid; P58406; -.
DR OMA; APGCWGC; -.
DR OrthoDB; 614573at2759; -.
DR PhylomeDB; P58406; -.
DR TreeFam; TF351747; -.
DR Reactome; R-MMU-390650; Histamine receptors.
DR BioGRID-ORCS; 99296; 3 hits in 72 CRISPR screens.
DR PRO; PR:P58406; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P58406; protein.
DR Bgee; ENSMUSG00000039059; Expressed in superior frontal gyrus and 56 other tissues.
DR ExpressionAtlas; P58406; baseline and differential.
DR Genevisible; P58406; MM.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043209; C:myelin sheath; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0043176; F:amine binding; ISO:MGI.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IBA:GO_Central.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:1901363; F:heterocyclic compound binding; ISO:MGI.
DR GO; GO:0004969; F:histamine receptor activity; IEA:InterPro.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007197; P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0050890; P:cognition; ISO:MGI.
DR GO; GO:0042756; P:drinking behavior; ISO:MGI.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007612; P:learning; ISO:MGI.
DR GO; GO:0007613; P:memory; ISO:MGI.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase activity; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; ISO:MGI.
DR GO; GO:0014053; P:negative regulation of gamma-aminobutyric acid secretion; ISO:MGI.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; ISO:MGI.
DR GO; GO:0014063; P:negative regulation of serotonin secretion; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:MGI.
DR GO; GO:0001505; P:regulation of neurotransmitter levels; IEA:InterPro.
DR GO; GO:0014061; P:regulation of norepinephrine secretion; ISO:MGI.
DR GO; GO:0014070; P:response to organic cyclic compound; ISO:MGI.
DR CDD; cd15296; 7tmA_Histamine_H3R; 1.
DR InterPro; IPR041998; 7tmA_HRH3.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003980; Histamine_H3_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01471; HISTAMINEH3R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..445
FT /note="Histamine H3 receptor"
FT /id="PRO_0000069691"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..396
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..445
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 234..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..259
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 439
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 11
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 445 AA; 48541 MW; B8D406E29E1F3C5F CRC64;
MERAPPDGLM NASGALAGEA AAAGGARGFS AAWTAVLAAL MALLIVATVL GNALVMLAFV
ADSSLRTQNN FFLLNLAISD FLVGAFCIPL YVPYVLTGRW TFGRGLCKLW LVVDYLLCAS
SVFNIVLISY DRFLSVTRAV SYRAQQGDTR RAVRKMALVW VLAFLLYGPA ILSWEYLSGG
SSIPEGHCYA EFFYNWYFLI TASTLEFFTP FLSVTFFNLS IYLNIQRRTR LRLDGGREAG
PEPPPDAQPS PPPAPPSCWG CWPKGHGEAM PLHRYGVGEA GPGVETGEAG LGGGSGGGAA
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL SRDKKVAKSL
AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL LWANSAVNPV LYPLCHYSFR
RAFTKLLCPQ KLKVQPHGSL EQCWK
