HRH4_MOUSE
ID HRH4_MOUSE Reviewed; 391 AA.
AC Q91ZY2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Histamine H4 receptor;
DE Short=H4R;
DE Short=HH4R;
GN Name=Hrh4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Liu C., Wilson S., Kuei C., Lovenberg T.W.;
RT "Comparison of human, mouse, rat, and guinea pig histamine H4 receptor
RT suggests substantial species variation.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The H4 subclass of histamine receptors could mediate the
CC histamine signals in peripheral tissues. Displays a significant level
CC of constitutive activity (spontaneous activity in the absence of
CC agonist) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF358859; AAK97380.1; -; mRNA.
DR CCDS; CCDS29069.1; -.
DR RefSeq; NP_694727.1; NM_153087.2.
DR AlphaFoldDB; Q91ZY2; -.
DR SMR; Q91ZY2; -.
DR STRING; 10090.ENSMUSP00000041061; -.
DR BindingDB; Q91ZY2; -.
DR ChEMBL; CHEMBL5657; -.
DR DrugCentral; Q91ZY2; -.
DR GuidetoPHARMACOLOGY; 265; -.
DR GlyGen; Q91ZY2; 2 sites.
DR iPTMnet; Q91ZY2; -.
DR PhosphoSitePlus; Q91ZY2; -.
DR PaxDb; Q91ZY2; -.
DR PRIDE; Q91ZY2; -.
DR ProteomicsDB; 273045; -.
DR Antibodypedia; 7806; 295 antibodies from 29 providers.
DR DNASU; 225192; -.
DR Ensembl; ENSMUST00000041676; ENSMUSP00000041061; ENSMUSG00000037346.
DR GeneID; 225192; -.
DR KEGG; mmu:225192; -.
DR UCSC; uc008edb.1; mouse.
DR CTD; 59340; -.
DR MGI; MGI:2429635; Hrh4.
DR VEuPathDB; HostDB:ENSMUSG00000037346; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000162118; -.
DR HOGENOM; CLU_009579_11_2_1; -.
DR InParanoid; Q91ZY2; -.
DR OMA; VSYRTQH; -.
DR OrthoDB; 614573at2759; -.
DR PhylomeDB; Q91ZY2; -.
DR TreeFam; TF351747; -.
DR Reactome; R-MMU-390650; Histamine receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 225192; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q91ZY2; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q91ZY2; protein.
DR Bgee; ENSMUSG00000037346; Expressed in spermatocyte and 4 other tissues.
DR ExpressionAtlas; Q91ZY2; baseline and differential.
DR Genevisible; Q91ZY2; MM.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IBA:GO_Central.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0004969; F:histamine receptor activity; IDA:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007197; P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008102; Histamine_H4_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01726; HISTAMINEH4R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..391
FT /note="Histamine H4 receptor"
FT /id="PRO_0000303238"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..391
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 238..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 87..166
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 391 AA; 44249 MW; 59EC73CB5214C5E0 CRC64;
MSESNSTGIL PPAAQVPLAF LMSSFAFAIM VGNAVVILAF VVDRNLRHRS NYFFLNLAIS
DFLVGLISIP LYIPHVLFNW NFGSGICMFW LITDYLLCTA SVYNIVLISY DRYQSVSNAV
SYRAQHTGIM KIVAQMVAVW ILAFLVNGPM ILASDSWKNS TNTKDCEPGF VTEWYILTIT
MLLEFLLPVI SVAYFNVQIY WSLWKRRALS RCPSHAGFST TSSSASGHLH RAGVACRTSN
PGLKESAASR HSESPRRKSS ILVSLRTHMN SSITAFKVGS FWRSESAALR QREYAELLRG
RKLARSLAIL LSAFAICWAP YCLFTIVLST YPRTERPKSV WYSIAFWLQW FNSFVNPFLY
PLCHRRFQKA FWKILCVTKQ PALSQNQSVS S
