HRH4_RAT
ID HRH4_RAT Reviewed; 391 AA.
AC Q91ZY1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Histamine H4 receptor;
DE Short=H4R;
DE Short=HH4R;
GN Name=Hrh4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Liu C., Wilson S., Kuei C., Lovenberg T.W.;
RT "Comparison of human, mouse, rat, and guinea pig histamine H4 receptor
RT suggests substantial species variation.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The H4 subclass of histamine receptors could mediate the
CC histamine signals in peripheral tissues. Displays a significant level
CC of constitutive activity (spontaneous activity in the absence of
CC agonist) (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF358860; AAK97381.1; -; mRNA.
DR RefSeq; NP_571984.1; NM_131909.1.
DR AlphaFoldDB; Q91ZY1; -.
DR SMR; Q91ZY1; -.
DR STRING; 10116.ENSRNOP00000022744; -.
DR BindingDB; Q91ZY1; -.
DR ChEMBL; CHEMBL4468; -.
DR DrugCentral; Q91ZY1; -.
DR GuidetoPHARMACOLOGY; 265; -.
DR GlyGen; Q91ZY1; 2 sites.
DR PhosphoSitePlus; Q91ZY1; -.
DR PaxDb; Q91ZY1; -.
DR GeneID; 170704; -.
DR KEGG; rno:170704; -.
DR CTD; 59340; -.
DR RGD; 620631; Hrh4.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q91ZY1; -.
DR OrthoDB; 614573at2759; -.
DR PhylomeDB; Q91ZY1; -.
DR Reactome; R-RNO-390650; Histamine receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q91ZY1; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IBA:GO_Central.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0004969; F:histamine receptor activity; IDA:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007197; P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IMP:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008102; Histamine_H4_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01726; HISTAMINEH4R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..391
FT /note="Histamine H4 receptor"
FT /id="PRO_0000303239"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..391
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 87..166
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 391 AA; 44023 MW; C707BA6E39CFED41 CRC64;
MSESNGTDVL PLTAQVPLAF LMSLLAFAIT IGNAVVILAF VADRNLRHRS NYFFLNLAIS
DFFVGVISIP LYIPHTLFNW NFGSGICMFW LITDYLLCTA SVYSIVLISY DRYQSVSNAV
RYRAQHTGIL KIVAQMVAVW ILAFLVNGPM ILASDSWKNS TNTEECEPGF VTEWYILAIT
AFLEFLLPVS LVVYFSVQIY WSLWKRGSLS RCPSHAGFIA TSSRGTGHSR RTGLACRTSL
PGLKEPAASL HSESPRGKSS LLVSLRTHMS GSIIAFKVGS FCRSESPVLH QREHVELLRG
RKLARSLAVL LSAFAICWAP YCLFTIVLST YRRGERPKSI WYSIAFWLQW FNSLINPFLY
PLCHRRFQKA FWKILCVTKQ PAPSQTQSVS S
