HRK_MOUSE
ID HRK_MOUSE Reviewed; 92 AA.
AC P62816; P70678;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Activator of apoptosis harakiri;
DE AltName: Full=BH3-interacting domain-containing protein 3;
DE AltName: Full=Neuronal death protein DP5;
GN Name=Hrk; Synonyms=Bid3, Dp5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9228060; DOI=10.1074/jbc.272.30.18842;
RA Imaizumi K., Tsuda M., Imai Y., Wanaka A., Takagi T., Tohyama M.;
RT "Molecular cloning of a novel polypeptide, DP5, induced during programmed
RT neuronal death.";
RL J. Biol. Chem. 272:18842-18848(1997).
CC -!- FUNCTION: Promotes apoptosis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with BCL2 and BCL2L1. Interacts with C1QBP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC protein {ECO:0000250}. Mitochondrion {ECO:0000250}.
CC -!- DOMAIN: The BH3 motif is required for the induction of cell death.
CC {ECO:0000250}.
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DR EMBL; D83698; BAA12066.1; -; mRNA.
DR CCDS; CCDS39236.1; -.
DR RefSeq; NP_031571.1; NM_007545.2.
DR AlphaFoldDB; P62816; -.
DR SMR; P62816; -.
DR IntAct; P62816; 1.
DR MINT; P62816; -.
DR STRING; 10090.ENSMUSP00000057532; -.
DR PaxDb; P62816; -.
DR PRIDE; P62816; -.
DR Antibodypedia; 18831; 208 antibodies from 29 providers.
DR Ensembl; ENSMUST00000054836; ENSMUSP00000057532; ENSMUSG00000046607.
DR GeneID; 12123; -.
DR KEGG; mmu:12123; -.
DR UCSC; uc008zgg.1; mouse.
DR CTD; 8739; -.
DR MGI; MGI:1201608; Hrk.
DR VEuPathDB; HostDB:ENSMUSG00000046607; -.
DR eggNOG; ENOG502T2F4; Eukaryota.
DR GeneTree; ENSGT00390000007050; -.
DR HOGENOM; CLU_2426351_0_0_1; -.
DR InParanoid; P62816; -.
DR OMA; QERTMWR; -.
DR OrthoDB; 1642993at2759; -.
DR TreeFam; TF338168; -.
DR BioGRID-ORCS; 12123; 1 hit in 67 CRISPR screens.
DR ChiTaRS; Hrk; mouse.
DR PRO; PR:P62816; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P62816; protein.
DR Bgee; ENSMUSG00000046607; Expressed in dentate gyrus of hippocampal formation granule cell and 99 other tissues.
DR Genevisible; P62816; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR GO; GO:0051365; P:cellular response to potassium ion starvation; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISO:MGI.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; ISO:MGI.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISO:MGI.
DR InterPro; IPR017249; Apoptosis_activator_harakiri.
DR InterPro; IPR020728; Bcl2_BH3_motif_CS.
DR PANTHER; PTHR15056; PTHR15056; 1.
DR Pfam; PF15196; Harakiri; 1.
DR PIRSF; PIRSF037635; BID3; 1.
DR PROSITE; PS01259; BH3; 1.
PE 3: Inferred from homology;
KW Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..92
FT /note="Activator of apoptosis harakiri"
FT /id="PRO_0000143107"
FT TRANSMEM 70..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOTIF 33..47
FT /note="BH3"
SQ SEQUENCE 92 AA; 10078 MW; 95760B9EEA88F1DE CRC64;
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR RRARPRDPLP
ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
